| 1 | Sat 7 Aug 2021 | 61-1 v MillwallQueens Park Rangers 1-1 Millwall |
| 2 | Sat 14 Aug 2021 | 63-0 v Hull CityHull City 0-3 Queens Park Rangers |
| 3 | Wed 18 Aug 2021 | 63-2 v MiddlesbroughMiddlesbrough 2-3 Queens Park Rangers |
| 4 | Sat 21 Aug 2021 | 6 2-2 v BarnsleyQueens Park Rangers 2-2 Barnsley |
| 5 | Sat 28 Aug 2021 | 62-0 v Coventry CityQueens Park Rangers 2-0 Coventry City |
| 6 | Sat 11 Sep 2021 | 63-3 v ReadingReading 3-3 Queens Park Rangers |
| 7 | Tue 14 Sep 2021 | 6 1-2 v AFC BournemouthAFC Bournemouth 2-1 Queens Park Rangers |
| 8 | Sat 18 Sep 2021 | 6 1-2 v Bristol CityQueens Park Rangers 1-2 Bristol City |
| 9 | Fri 24 Sep 2021 | 61-2 v West Bromwich AlbionWest Bromwich Albion 2-1 Queens Park Rangers |
| 10 | Tue 28 Sep 2021 | 62-0 v Birmingham CityQueens Park Rangers 2-0 Birmingham City |
| 11 | Sat 2 Oct 2021 | 63-2 v Preston North EndQueens Park Rangers 3-2 Preston North End |
| 12 | Sat 16 Oct 2021 | 61-4 v FulhamFulham 4-1 Queens Park Rangers |
| 13 | Sat 23 Oct 2021 | 61-2 v Peterborough UnitedPeterborough United 2-1 Queens Park Rangers |
| 14 | Fri 29 Oct 2021 | 61-1 v Nottingham ForestQueens Park Rangers 1-1 Nottingham Forest |
| 15 | Wed 3 Nov 2021 | 61-0 v Cardiff CityCardiff City 0-1 Queens Park Rangers |
| 16 | Sat 6 Nov 2021 | 61-1 v BlackpoolBlackpool 1-1 Queens Park Rangers |
| 17 | Fri 19 Nov 2021 | 62-0 v Luton TownQueens Park Rangers 2-0 Luton Town |
| 18 | Wed 24 Nov 2021 | 61-0 v Huddersfield TownQueens Park Rangers 1-0 Huddersfield Town |
| 19 | Mon 29 Nov 2021 | 62-1 v Derby CountyDerby County 1-2 Queens Park Rangers |
| 20 | Sun 5 Dec 2021 | 60-2 v Stoke CityQueens Park Rangers 0-2 Stoke City |
| 21 | Mon 27 Dec 2021 | 6 0-1 v AFC BournemouthQueens Park Rangers 0-1 AFC Bournemouth |
| 22 | Thu 30 Dec 2021 | 62-1 v Bristol CityBristol City 1-2 Queens Park Rangers |
| 23 | Sun 2 Jan 2022 | 62-1 v Birmingham CityBirmingham City 1-2 Queens Park Rangers |
| 24 | Sat 15 Jan 2022 | 61-0 v West Bromwich AlbionQueens Park Rangers 1-0 West Bromwich Albion |
| 25 | Sat 22 Jan 2022 | 62-1 v Coventry CityCoventry City 1-2 Queens Park Rangers |
| 26 | Tue 25 Jan 2022 | 60-0 v Swansea CityQueens Park Rangers 0-0 Swansea City |
| 27 | Sat 29 Jan 2022 | 64-0 v ReadingQueens Park Rangers 4-0 Reading |
| 28 | Wed 9 Feb 2022 | 62-2 v MiddlesbroughQueens Park Rangers 2-2 Middlesbrough |
| 29 | Sat 12 Feb 2022 | 60-1 v BarnsleyBarnsley 1-0 Queens Park Rangers |
| 30 | Tue 15 Feb 2022 | 60-2 v MillwallMillwall 2-0 Queens Park Rangers |
| 31 | Sat 19 Feb 2022 | 61-1 v Hull CityQueens Park Rangers 1-1 Hull City |
| 32 | Wed 23 Feb 2022 | 62-1 v BlackpoolQueens Park Rangers 2-1 Blackpool |
| 33 | Sat 26 Feb 2022 | 60-1 v Blackburn RoversBlackburn Rovers 1-0 Queens Park Rangers |
| 34 | Sat 5 Mar 2022 | 61-2 v Cardiff CityQueens Park Rangers 1-2 Cardiff City |
| 35 | Sun 13 Mar 2022 | 62-1 v Luton TownLuton Town 1-2 Queens Park Rangers |
| 36 | Sat 2 Apr 2022 | 6 0-2 v FulhamQueens Park Rangers 0-2 Fulham |
| 37 | Tue 5 Apr 2022 | 60-1 v Sheffield UnitedSheffield United 1-0 Queens Park Rangers |
| 38 | Fri 15 Apr 2022 | 62-2 v Huddersfield TownHuddersfield Town 2-2 Queens Park Rangers |
| 39 | Sat 23 Apr 2022 | 60-1 v Stoke CityStoke City 1-0 Queens Park Rangers |
| 40 | Sat 7 May 2022 | 61-0 v Swansea CitySwansea City 0-1 Queens Park Rangers |
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