| 1 | Sat 14 Aug 2021 | 43-0 v Crystal PalaceChelsea 3-0 Crystal Palace | Premier League |
| 2 | Sun 22 Aug 2021 | 42-0 v ArsenalArsenal 0-2 Chelsea | Premier League |
| 3 | Sat 28 Aug 2021 | 41-1 v LiverpoolLiverpool 1-1 Chelsea | Premier League |
| 4 | Tue 14 Sep 2021 | 41-0 v Zenit St PetersburgChelsea 1-0 Zenit St Petersburg | UEFA Champions League Group H |
| 5 | Sun 19 Sep 2021 | 43-0 v Tottenham HotspurTottenham Hotspur 0-3 Chelsea | Premier League |
| 6 | Sat 25 Sep 2021 | 4 0-1 v Manchester CityChelsea 0-1 Manchester City | Premier League |
| 7 | Wed 29 Sep 2021 | 40-1 v JuventusJuventus 1-0 Chelsea | UEFA Champions League Group H |
| 8 | Sat 16 Oct 2021 | 41-0 v BrentfordBrentford 0-1 Chelsea | Premier League |
| 9 | Wed 20 Oct 2021 | 44-0 v Malmö FFChelsea 4-0 Malmö FF | UEFA Champions League Group H |
| 10 | Sat 30 Oct 2021 | 43-0 v Newcastle UnitedNewcastle United 0-3 Chelsea | Premier League |
| 11 | Tue 2 Nov 2021 | 41-0 v Malmö FFMalmö FF 0-1 Chelsea | UEFA Champions League Group H |
| 12 | Sat 6 Nov 2021 | 41-1 v BurnleyChelsea 1-1 Burnley | Premier League |
| 13 | Wed 1 Dec 2021 | 42-1 v WatfordWatford 1-2 Chelsea | Premier League |
| 14 | Sat 4 Dec 2021 | 4 2-3 v West Ham UnitedWest Ham United 3-2 Chelsea | Premier League |
| 15 | Wed 8 Dec 2021 | 43-3 v Zenit St PetersburgZenit St Petersburg 3-3 Chelsea | UEFA Champions League Group H |
| 16 | Sat 11 Dec 2021 | 43-2 v Leeds UnitedChelsea 3-2 Leeds United | Premier League |
| 17 | Sun 26 Dec 2021 | 43-1 v Aston VillaAston Villa 1-3 Chelsea | Premier League |
| 18 | Wed 29 Dec 2021 | 41-1 v Brighton & Hove AlbionChelsea 1-1 Brighton & Hove Albion | Premier League |
| 19 | Sat 8 Jan 2022 | 45-1 v ChesterfieldChelsea 5-1 Chesterfield | Emirates FA Cup Third Round |
| 20 | Wed 12 Jan 2022 | 41-0 v Tottenham HotspurTottenham Hotspur 0-1 Chelsea | Carabao Cup Semi Final |
| 21 | Sat 5 Feb 2022 | 42-1 v Plymouth ArgyleChelsea 2-1 Plymouth Argyle | Emirates FA Cup Fourth Round |
| 22 | Sat 19 Feb 2022 | 41-0 v Crystal PalaceCrystal Palace 0-1 Chelsea | Premier League |
| 23 | Tue 22 Feb 2022 | 42-0 v LilleChelsea 2-0 Lille | UEFA Champions League Round of 16 |
| 24 | Thu 10 Mar 2022 | 43-1 v Norwich CityNorwich City 1-3 Chelsea | Premier League |
| 25 | Sun 13 Mar 2022 | 41-0 v Newcastle UnitedChelsea 1-0 Newcastle United | Premier League |
| 26 | Wed 16 Mar 2022 | 42-1 v LilleLille 1-2 Chelsea | UEFA Champions League Round of 16 |
| 27 | Wed 6 Apr 2022 | 41-3 v Real MadridChelsea 1-3 Real Madrid | UEFA Champions League Quarter Final |
| 28 | Sat 9 Apr 2022 | 46-0 v SouthamptonSouthampton 0-6 Chelsea | Premier League |
| 29 | Sun 17 Apr 2022 | 42-0 v Crystal PalaceChelsea 2-0 Crystal Palace | Emirates FA Cup Semi Final |
| 30 | Wed 20 Apr 2022 | 42-4 v ArsenalChelsea 2-4 Arsenal | Premier League |
| 31 | Sun 24 Apr 2022 | 41-0 v West Ham UnitedChelsea 1-0 West Ham United | Premier League |
| 32 | Wed 11 May 2022 | 43-0 v Leeds UnitedLeeds United 0-3 Chelsea | Premier League |
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