| 1 | Sat 22 Jan 2022 | 173-0 v Salford CitySalford City 0-3 Colchester United | Sky Bet League Two |
| 2 | Sat 29 Jan 2022 | 171-1 v Swindon TownColchester United 1-1 Swindon Town | Sky Bet League Two |
| 3 | Tue 1 Feb 2022 | 171-1 v RochdaleColchester United 1-1 Rochdale | Sky Bet League Two |
| 4 | Sat 5 Feb 2022 | 171-0 v Leyton OrientLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 5 | Tue 8 Feb 2022 | 171-2 v Mansfield TownMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 6 | Sat 12 Feb 2022 | 172-2 v Carlisle UnitedColchester United 2-2 Carlisle United | Sky Bet League Two |
| 7 | Sat 19 Feb 2022 | 170-3 v Northampton TownNorthampton Town 3-0 Colchester United | Sky Bet League Two |
| 8 | Tue 22 Feb 2022 | 171-2 v Hartlepool UnitedColchester United 1-2 Hartlepool United | Sky Bet League Two |
| 9 | Sat 26 Feb 2022 | 171-1 v Oldham AthleticColchester United 1-1 Oldham Athletic | Sky Bet League Two |
| 10 | Tue 1 Mar 2022 | 172-2 v Leyton OrientColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 11 | Sat 5 Mar 2022 | 171-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 12 | Sat 12 Mar 2022 | 173-1 v Scunthorpe UnitedScunthorpe United 1-3 Colchester United | Sky Bet League Two |
| 13 | Tue 15 Mar 2022 | 170-1 v Bristol RoversBristol Rovers 1-0 Colchester United | Sky Bet League Two |
| 14 | Mon 21 Mar 2022 | 170-1 v Forest Green RoversColchester United 0-1 Forest Green Rovers | Sky Bet League Two |
| 15 | Sat 26 Mar 2022 | 171-0 v Tranmere RoversColchester United 1-0 Tranmere Rovers | Sky Bet League Two |
| 16 | Sat 2 Apr 2022 | 172-1 v Harrogate TownHarrogate Town 1-2 Colchester United | Sky Bet League Two |
| 17 | Sat 9 Apr 2022 | 17 0-2 v StevenageColchester United 0-2 Stevenage | Sky Bet League Two |
| 18 | Mon 18 Apr 2022 | 173-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 19 | Fri 22 Apr 2022 | 172-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
| 20 | Sat 30 Apr 2022 | 172-2 v WalsallColchester United 2-2 Walsall | Sky Bet League Two |
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