| 1 | Sat 7 Aug 2021 | 170-0 v Carlisle UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | Tue 10 Aug 2021 | 170-1 v Birmingham CityBirmingham City 1-0 Colchester United | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 170-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 4 | Tue 17 Aug 2021 | 171-1 v Mansfield TownColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 5 | Sat 21 Aug 2021 | 172-1 v Oldham AthleticOldham Athletic 1-2 Colchester United | Sky Bet League Two |
| 6 | Fri 27 Aug 2021 | 171-1 v RochdaleRochdale 1-1 Colchester United | Sky Bet League Two |
| 7 | Tue 7 Sep 2021 | 170-1 v GillinghamColchester United 0-1 Gillingham | Papa John’s Trophy |
| 8 | Sat 18 Sep 2021 | 170-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 9 | Sat 25 Sep 2021 | 170-0 v Swindon TownSwindon Town 0-0 Colchester United | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 17 0-2 v Salford CityColchester United 0-2 Salford City | Sky Bet League Two |
| 11 | Fri 8 Oct 2021 | 17 0-2 v Tranmere RoversTranmere Rovers 2-0 Colchester United | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 171-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 171-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 14 | Sat 30 Oct 2021 | 172-1 v Scunthorpe UnitedColchester United 2-1 Scunthorpe United | Sky Bet League Two |
| 15 | Sat 20 Nov 2021 | 17 0-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 16 | Tue 23 Nov 2021 | 173-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 17 | Fri 26 Nov 2021 | 171-1 v Newport CountyColchester United 1-1 Newport County | Sky Bet League Two |
| 18 | Sun 5 Dec 2021 | 17 1-2 v Wigan AthleticColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 19 | Wed 8 Dec 2021 | 170-0 v Bradford CityBradford City 0-0 Colchester United | Sky Bet League Two |
| 20 | Sat 11 Dec 2021 | 170-3 v WalsallWalsall 3-0 Colchester United | Sky Bet League Two |
| 21 | Sat 1 Jan 2022 | 171-3 v Crawley TownCrawley Town 3-1 Colchester United | Sky Bet League Two |
Football Web Pages