| 1 | 7/8/2021 | 180-0 v Carlisle UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | 10/8/2021 | 180-1 v Birmingham CityBirmingham City 1-0 Colchester United | Carabao Cup First Round |
| 3 | 14/8/2021 | 180-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 4 | 17/8/2021 | 181-1 v Mansfield TownColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 5 | 27/8/2021 | 181-1 v RochdaleRochdale 1-1 Colchester United | Sky Bet League Two |
| 6 | 7/9/2021 | 180-1 v GillinghamColchester United 0-1 Gillingham | Checkatrade Trophy |
| 7 | 10/9/2021 | 183-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 8 | 18/9/2021 | 180-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 9 | 25/9/2021 | 180-0 v Swindon TownSwindon Town 0-0 Colchester United | Sky Bet League Two |
| 10 | 2/10/2021 | 180-2 v Salford CityColchester United 0-2 Salford City | Sky Bet League Two |
| 11 | 8/10/2021 | 180-2 v Tranmere RoversTranmere Rovers 2-0 Colchester United | Sky Bet League Two |
| 12 | 16/10/2021 | 181-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 13 | 19/10/2021 | 18 1-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 14 | 23/10/2021 | 180-3 v Port ValePort Vale 3-0 Colchester United | Sky Bet League Two |
| 15 | 26/10/2021 | 181-3 v Sutton UnitedColchester United 1-3 Sutton United | Sky Bet League Two |
| 16 | 30/10/2021 | 182-1 v Scunthorpe UnitedColchester United 2-1 Scunthorpe United | Sky Bet League Two |
| 17 | 9/11/2021 | 180-0 v Ipswich TownIpswich Town 0-0 Colchester United | Checkatrade Trophy |
| 18 | 20/11/2021 | 180-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 19 | 23/11/2021 | 183-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 20 | 26/11/2021 | 181-1 v Newport CountyColchester United 1-1 Newport County | Sky Bet League Two |
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