| 1 | 7/8/2021 | 50-0 v Carlisle UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | 10/8/2021 | 50-1 v Birmingham CityBirmingham City 1-0 Colchester United | Carabao Cup First Round |
| 3 | 14/8/2021 | 50-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 4 | 21/8/2021 | 52-1 v Oldham AthleticOldham Athletic 1-2 Colchester United | Sky Bet League Two |
| 5 | 27/8/2021 | 51-1 v RochdaleRochdale 1-1 Colchester United | Sky Bet League Two |
| 6 | 10/9/2021 | 53-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 7 | 18/9/2021 | 50-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 8 | 25/9/2021 | 50-0 v Swindon TownSwindon Town 0-0 Colchester United | Sky Bet League Two |
| 9 | 2/10/2021 | 50-2 v Salford CityColchester United 0-2 Salford City | Sky Bet League Two |
| 10 | 16/10/2021 | 51-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 11 | 19/10/2021 | 51-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 12 | 23/10/2021 | 50-3 v Port ValePort Vale 3-0 Colchester United | Sky Bet League Two |
| 13 | 26/10/2021 | 5 1-3 v Sutton UnitedColchester United 1-3 Sutton United | Sky Bet League Two |
| 14 | 30/10/2021 | 52-1 v Scunthorpe UnitedColchester United 2-1 Scunthorpe United | Sky Bet League Two |
| 15 | 20/11/2021 | 50-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 16 | 23/11/2021 | 53-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 17 | 26/11/2021 | 51-1 v Newport CountyColchester United 1-1 Newport County | Sky Bet League Two |
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