| 1 | Tue 31 Aug 2021 | 351-0 v Shrewsbury TownShrewsbury Town 0-1 Crewe Alexandra | Papa John’s Trophy |
| 2 | Sat 11 Sep 2021 | 35 1-1 v Shrewsbury TownShrewsbury Town 1-1 Crewe Alexandra | Sky Bet League One |
| 3 | Sat 18 Sep 2021 | 352-0 v Burton AlbionCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 4 | Tue 21 Sep 2021 | 351-3 v MorecambeCrewe Alexandra 1-3 Morecambe | Sky Bet League One |
| 5 | Sat 25 Sep 2021 | 351-1 v Rotherham UnitedRotherham United 1-1 Crewe Alexandra | Sky Bet League One |
| 6 | Tue 28 Sep 2021 | 35 1-1 v Plymouth ArgylePlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 7 | Sat 2 Oct 2021 | 352-2 v Cambridge UnitedCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 8 | Sat 16 Oct 2021 | 35 0-3 v Fleetwood TownFleetwood Town 3-0 Crewe Alexandra | Sky Bet League One |
| 9 | Tue 19 Oct 2021 | 350-4 v SunderlandCrewe Alexandra 0-4 Sunderland | Sky Bet League One |
| 10 | Sat 23 Oct 2021 | 351-2 v Wycombe WanderersWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 11 | Sat 30 Oct 2021 | 351-4 v Milton Keynes DonsCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 12 | Tue 2 Nov 2021 | 351-1 v Doncaster RoversCrewe Alexandra 1-1 Doncaster Rovers | Sky Bet League One |
| 13 | Sat 6 Nov 2021 | 35 0-3 v Swindon TownCrewe Alexandra 0-3 Swindon Town | Emirates FA Cup First Round |
| 14 | Fri 12 Nov 2021 | 350-2 v Bolton WanderersBolton Wanderers 2-0 Crewe Alexandra | Sky Bet League One |
| 15 | Sat 11 Dec 2021 | 35 0-2 v Sheffield WednesdayCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 16 | Wed 29 Dec 2021 | 352-1 v MorecambeMorecambe 1-2 Crewe Alexandra | Sky Bet League One |
| 17 | Sat 1 Jan 2022 | 351-4 v Burton AlbionBurton Albion 4-1 Crewe Alexandra | Sky Bet League One |
| 18 | Tue 4 Jan 2022 | 352-4 v Rotherham UnitedCrewe Alexandra 2-4 Rotherham United | Papa John’s Trophy Third Round |
| 19 | Wed 12 Jan 2022 | 352-1 v Charlton AthleticCrewe Alexandra 2-1 Charlton Athletic | Sky Bet League One |
| 20 | Sat 22 Jan 2022 | 350-1 v Cambridge UnitedCambridge United 1-0 Crewe Alexandra | Sky Bet League One |
| 21 | Sat 29 Jan 2022 | 35 0-2 v Rotherham UnitedCrewe Alexandra 0-2 Rotherham United | Sky Bet League One |
| 22 | Sat 12 Feb 2022 | 351-4 v Accrington StanleyAccrington Stanley 4-1 Crewe Alexandra | Sky Bet League One |
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