| 1 | Sat 12 Sep 2020 | 23 0-2 v sc Heerenveensc Heerenveen 2-0 Willem II |
| 2 | Sun 20 Sep 2020 | 234-0 v Heracles AlmeloWillem II 4-0 Heracles Almelo |
| 3 | Sun 27 Sep 2020 | 231-1 v FC EmmenFC Emmen 1-1 Willem II |
| 4 | Sun 4 Oct 2020 | 231-4 v FeyenoordWillem II 1-4 Feyenoord |
| 5 | Sat 17 Oct 2020 | 23 0-3 v FC TwenteWillem II 0-3 FC Twente |
| 6 | Sat 24 Oct 2020 | 230-0 v PEC ZwollePEC Zwolle 0-0 Willem II |
| 7 | Sat 31 Oct 2020 | 231-3 v VitesseWillem II 1-3 Vitesse |
| 8 | Sun 8 Nov 2020 | 230-3 v PSV EindhovenPSV Eindhoven 3-0 Willem II |
| 9 | Sat 21 Nov 2020 | 232-1 v VVV VenloWillem II 2-1 VVV Venlo |
| 10 | Sun 29 Nov 2020 | 23 0-1 v FC GroningenFC Groningen 1-0 Willem II |
| 11 | Sat 5 Dec 2020 | 232-3 v Fortuna SittardFortuna Sittard 3-2 Willem II |
| 12 | Sun 13 Dec 2020 | 23 1-3 v Sparta RotterdamWillem II 1-3 Sparta Rotterdam |
| 13 | Sun 20 Dec 2020 | 233-5 v AZ AlkmaarAZ Alkmaar 5-3 Willem II |
| 14 | Wed 23 Dec 2020 | 231-1 v AjaxWillem II 1-1 Ajax |
| 15 | Sun 10 Jan 2021 | 231-2 v VVV VenloVVV Venlo 2-1 Willem II |
| 16 | Thu 14 Jan 2021 | 232-3 v FC GroningenWillem II 2-3 FC Groningen |
| 17 | Sun 17 Jan 2021 | 231-1 v RKC WaalwijkRKC Waalwijk 1-1 Willem II |
| 18 | Fri 22 Jan 2021 | 231-3 v PEC ZwolleWillem II 1-3 PEC Zwolle |
| 19 | Fri 19 Feb 2021 | 230-6 v FC UtrechtWillem II 0-6 FC Utrecht |
| 20 | Sat 13 Mar 2021 | 233-1 v sc HeerenveenWillem II 3-1 sc Heerenveen |
| 21 | Sat 10 Apr 2021 | 230-4 v Heracles AlmeloHeracles Almelo 4-0 Willem II |
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