| 1 | Sun 20 Sep 2020 | 44-0 v Heracles AlmeloWillem II 4-0 Heracles Almelo |
| 2 | Sun 4 Oct 2020 | 4 1-4 v FeyenoordWillem II 1-4 Feyenoord |
| 3 | Sat 24 Oct 2020 | 40-0 v PEC ZwollePEC Zwolle 0-0 Willem II |
| 4 | Sat 31 Oct 2020 | 4 1-3 v VitesseWillem II 1-3 Vitesse |
| 5 | Sun 8 Nov 2020 | 40-3 v PSV EindhovenPSV Eindhoven 3-0 Willem II |
| 6 | Sat 21 Nov 2020 | 42-1 v VVV VenloWillem II 2-1 VVV Venlo |
| 7 | Sun 29 Nov 2020 | 40-1 v FC GroningenFC Groningen 1-0 Willem II |
| 8 | Sat 5 Dec 2020 | 42-3 v Fortuna SittardFortuna Sittard 3-2 Willem II |
| 9 | Sun 13 Dec 2020 | 41-3 v Sparta RotterdamWillem II 1-3 Sparta Rotterdam |
| 10 | Fri 22 Jan 2021 | 41-3 v PEC ZwolleWillem II 1-3 PEC Zwolle |
| 11 | Thu 28 Jan 2021 | 41-3 v AjaxAjax 3-1 Willem II |
| 12 | Sun 14 Feb 2021 | 40-5 v FeyenoordFeyenoord 5-0 Willem II |
| 13 | Fri 19 Feb 2021 | 40-6 v FC UtrechtWillem II 0-6 FC Utrecht |
| 14 | Wed 24 Feb 2021 | 4 1-1 v ADO Den HaagWillem II 1-1 ADO Den Haag |
| 15 | Sat 6 Mar 2021 | 41-1 v FC TwenteFC Twente 1-1 Willem II |
| 16 | Sat 1 May 2021 | 42-3 v FC UtrechtFC Utrecht 3-2 Willem II |
| 17 | Sun 9 May 2021 | 40-2 v PSV EindhovenWillem II 0-2 PSV Eindhoven |
| 18 | Sun 16 May 2021 | 42-1 v Fortuna SittardWillem II 2-1 Fortuna Sittard |
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