| 1 | Sun 20 Sep 2020 | 41-1 v FeyenoordFeyenoord 1-1 FC Twente |
| 2 | Fri 25 Sep 2020 | 43-1 v FC GroningenFC Twente 3-1 FC Groningen |
| 3 | Sat 3 Oct 2020 | 41-1 v FC EmmenFC Twente 1-1 FC Emmen |
| 4 | Sat 17 Oct 2020 | 43-0 v Willem IIWillem II 0-3 FC Twente |
| 5 | Sat 24 Oct 2020 | 4 1-2 v FC UtrechtFC Utrecht 2-1 FC Twente |
| 6 | Sat 31 Oct 2020 | 45-1 v PEC ZwolleFC Twente 5-1 PEC Zwolle |
| 7 | Sat 7 Nov 2020 | 44-2 v ADO Den HaagADO Den Haag 2-4 FC Twente |
| 8 | Sun 22 Nov 2020 | 4 1-1 v PSV EindhovenFC Twente 1-1 PSV Eindhoven |
| 9 | Fri 27 Nov 2020 | 4 0-2 v RKC WaalwijkFC Twente 0-2 RKC Waalwijk |
| 10 | Sat 5 Dec 2020 | 42-1 v AjaxAjax 1-2 FC Twente |
| 11 | Sun 13 Dec 2020 | 41-3 v AZ AlkmaarFC Twente 1-3 AZ Alkmaar |
| 12 | Sat 19 Dec 2020 | 42-1 v VVV VenloVVV Venlo 1-2 FC Twente |
| 13 | Tue 22 Dec 2020 | 40-2 v Sparta RotterdamFC Twente 0-2 Sparta Rotterdam |
| 14 | Sat 9 Jan 2021 | 44-1 v FC EmmenFC Emmen 1-4 FC Twente |
| 15 | Thu 14 Jan 2021 | 41-3 v AjaxFC Twente 1-3 Ajax |
| 16 | Sun 17 Jan 2021 | 42-2 v FC GroningenFC Groningen 2-2 FC Twente |
| 17 | Sun 24 Jan 2021 | 40-1 v VVV VenloFC Twente 0-1 VVV Venlo |
| 18 | Sat 6 Feb 2021 | 40-3 v PSV EindhovenPSV Eindhoven 3-0 FC Twente |
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