| 1 | Sat 5 Dec 2020 | 202-3 v Fortuna SittardFortuna Sittard 3-2 Willem II |
| 2 | Sun 13 Dec 2020 | 201-3 v Sparta RotterdamWillem II 1-3 Sparta Rotterdam |
| 3 | Sun 20 Dec 2020 | 203-5 v AZ AlkmaarAZ Alkmaar 5-3 Willem II |
| 4 | Wed 23 Dec 2020 | 201-1 v AjaxWillem II 1-1 Ajax |
| 5 | Sun 10 Jan 2021 | 201-2 v VVV VenloVVV Venlo 2-1 Willem II |
| 6 | Thu 14 Jan 2021 | 202-3 v FC GroningenWillem II 2-3 FC Groningen |
| 7 | Sun 17 Jan 2021 | 201-1 v RKC WaalwijkRKC Waalwijk 1-1 Willem II |
| 8 | Fri 22 Jan 2021 | 20 1-3 v PEC ZwolleWillem II 1-3 PEC Zwolle |
| 9 | Thu 28 Jan 2021 | 201-3 v AjaxAjax 3-1 Willem II |
| 10 | Sun 31 Jan 2021 | 202-0 v FC EmmenWillem II 2-0 FC Emmen |
| 11 | Sun 14 Feb 2021 | 200-5 v FeyenoordFeyenoord 5-0 Willem II |
| 12 | Fri 19 Feb 2021 | 200-6 v FC UtrechtWillem II 0-6 FC Utrecht |
| 13 | Wed 24 Feb 2021 | 201-1 v ADO Den HaagWillem II 1-1 ADO Den Haag |
| 14 | Sun 28 Feb 2021 | 202-0 v Sparta RotterdamSparta Rotterdam 0-2 Willem II |
| 15 | Sat 6 Mar 2021 | 201-1 v FC TwenteFC Twente 1-1 Willem II |
| 16 | Sat 13 Mar 2021 | 203-1 v sc HeerenveenWillem II 3-1 sc Heerenveen |
| 17 | Sun 21 Mar 2021 | 200-0 v VitesseVitesse 0-0 Willem II |
| 18 | Sat 3 Apr 2021 | 200-1 v AZ AlkmaarWillem II 0-1 AZ Alkmaar |
| 19 | Sat 10 Apr 2021 | 200-4 v Heracles AlmeloHeracles Almelo 4-0 Willem II |
| 20 | Fri 23 Apr 2021 | 201-0 v RKC WaalwijkWillem II 1-0 RKC Waalwijk |
| 21 | Sat 1 May 2021 | 20 2-3 v FC UtrechtFC Utrecht 3-2 Willem II |
| 22 | Sun 9 May 2021 | 200-2 v PSV EindhovenWillem II 0-2 PSV Eindhoven |
| 23 | Thu 13 May 2021 | 204-1 v ADO Den HaagADO Den Haag 1-4 Willem II |
| 24 | Sun 16 May 2021 | 202-1 v Fortuna SittardWillem II 2-1 Fortuna Sittard |
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