| 1 | Sat 31 Oct 2020 | 85-1 v PEC ZwolleFC Twente 5-1 PEC Zwolle |
| 2 | Sat 7 Nov 2020 | 84-2 v ADO Den HaagADO Den Haag 2-4 FC Twente |
| 3 | Sun 22 Nov 2020 | 81-1 v PSV EindhovenFC Twente 1-1 PSV Eindhoven |
| 4 | Fri 27 Nov 2020 | 80-2 v RKC WaalwijkFC Twente 0-2 RKC Waalwijk |
| 5 | Sat 5 Dec 2020 | 82-1 v AjaxAjax 1-2 FC Twente |
| 6 | Sun 13 Dec 2020 | 81-3 v AZ AlkmaarFC Twente 1-3 AZ Alkmaar |
| 7 | Sat 19 Dec 2020 | 8 2-1 v VVV VenloVVV Venlo 1-2 FC Twente |
| 8 | Tue 22 Dec 2020 | 80-2 v Sparta RotterdamFC Twente 0-2 Sparta Rotterdam |
| 9 | Sat 9 Jan 2021 | 84-1 v FC EmmenFC Emmen 1-4 FC Twente |
| 10 | Thu 14 Jan 2021 | 81-3 v AjaxFC Twente 1-3 Ajax |
| 11 | Sun 17 Jan 2021 | 82-2 v FC GroningenFC Groningen 2-2 FC Twente |
| 12 | Sun 24 Jan 2021 | 80-1 v VVV VenloFC Twente 0-1 VVV Venlo |
| 13 | Thu 28 Jan 2021 | 80-0 v Sparta RotterdamSparta Rotterdam 0-0 FC Twente |
| 14 | Sun 31 Jan 2021 | 80-0 v sc HeerenveenFC Twente 0-0 sc Heerenveen |
| 15 | Sat 6 Feb 2021 | 8 0-3 v PSV EindhovenPSV Eindhoven 3-0 FC Twente |
| 16 | Sat 6 Mar 2021 | 81-1 v Willem IIFC Twente 1-1 Willem II |
| 17 | Sat 13 Mar 2021 | 81-4 v AZ AlkmaarAZ Alkmaar 4-1 FC Twente |
| 18 | Fri 19 Mar 2021 | 80-0 v sc Heerenveensc Heerenveen 0-0 FC Twente |
| 19 | Sat 3 Apr 2021 | 81-2 v VitesseFC Twente 1-2 Vitesse |
| 20 | Sat 10 Apr 2021 | 80-1 v PEC ZwollePEC Zwolle 1-0 FC Twente |
| 21 | Sat 1 May 2021 | 80-3 v Fortuna SittardFortuna Sittard 3-0 FC Twente |
| 22 | Sat 8 May 2021 | 81-1 v Heracles AlmeloFC Twente 1-1 Heracles Almelo |
| 23 | Thu 13 May 2021 | 81-2 v RKC WaalwijkRKC Waalwijk 2-1 FC Twente |
| 24 | Sun 16 May 2021 | 83-2 v ADO Den HaagFC Twente 3-2 ADO Den Haag |
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