| 1 | Sat 12 Sep 2020 | 8 0-2 v sc Heerenveensc Heerenveen 2-0 Willem II |
| 2 | Sun 20 Sep 2020 | 84-0 v Heracles AlmeloWillem II 4-0 Heracles Almelo |
| 3 | Sun 27 Sep 2020 | 81-1 v FC EmmenFC Emmen 1-1 Willem II |
| 4 | Sun 4 Oct 2020 | 81-4 v FeyenoordWillem II 1-4 Feyenoord |
| 5 | Sat 24 Oct 2020 | 80-0 v PEC ZwollePEC Zwolle 0-0 Willem II |
| 6 | Sat 31 Oct 2020 | 81-3 v VitesseWillem II 1-3 Vitesse |
| 7 | Sun 8 Nov 2020 | 80-3 v PSV EindhovenPSV Eindhoven 3-0 Willem II |
| 8 | Sat 21 Nov 2020 | 8 2-1 v VVV VenloWillem II 2-1 VVV Venlo |
| 9 | Sun 29 Nov 2020 | 80-1 v FC GroningenFC Groningen 1-0 Willem II |
| 10 | Sat 5 Dec 2020 | 8 2-3 v Fortuna SittardFortuna Sittard 3-2 Willem II |
| 11 | Thu 14 Jan 2021 | 82-3 v FC GroningenWillem II 2-3 FC Groningen |
| 12 | Sun 17 Jan 2021 | 8 1-1 v RKC WaalwijkRKC Waalwijk 1-1 Willem II |
| 13 | Fri 22 Jan 2021 | 81-3 v PEC ZwolleWillem II 1-3 PEC Zwolle |
| 14 | Thu 28 Jan 2021 | 81-3 v AjaxAjax 3-1 Willem II |
| 15 | Sun 31 Jan 2021 | 82-0 v FC EmmenWillem II 2-0 FC Emmen |
| 16 | Wed 24 Feb 2021 | 81-1 v ADO Den HaagWillem II 1-1 ADO Den Haag |
| 17 | Sun 28 Feb 2021 | 82-0 v Sparta RotterdamSparta Rotterdam 0-2 Willem II |
| 18 | Sat 6 Mar 2021 | 81-1 v FC TwenteFC Twente 1-1 Willem II |
| 19 | Sat 13 Mar 2021 | 83-1 v sc HeerenveenWillem II 3-1 sc Heerenveen |
| 20 | Sun 21 Mar 2021 | 80-0 v VitesseVitesse 0-0 Willem II |
| 21 | Sat 3 Apr 2021 | 8 0-1 v AZ AlkmaarWillem II 0-1 AZ Alkmaar |
| 22 | Sat 10 Apr 2021 | 80-4 v Heracles AlmeloHeracles Almelo 4-0 Willem II |
| 23 | Fri 23 Apr 2021 | 81-0 v RKC WaalwijkWillem II 1-0 RKC Waalwijk |
| 24 | Sat 1 May 2021 | 82-3 v FC UtrechtFC Utrecht 3-2 Willem II |
| 25 | Sun 9 May 2021 | 80-2 v PSV EindhovenWillem II 0-2 PSV Eindhoven |
| 26 | Thu 13 May 2021 | 84-1 v ADO Den HaagADO Den Haag 1-4 Willem II |
| 27 | Sun 16 May 2021 | 8 2-1 v Fortuna SittardWillem II 2-1 Fortuna Sittard |
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