| 1 | Sat 5 Dec 2020 | 432-3 v Fortuna SittardFortuna Sittard 3-2 Willem II |
| 2 | Sun 13 Dec 2020 | 431-3 v Sparta RotterdamWillem II 1-3 Sparta Rotterdam |
| 3 | Sun 20 Dec 2020 | 433-5 v AZ AlkmaarAZ Alkmaar 5-3 Willem II |
| 4 | Wed 23 Dec 2020 | 431-1 v AjaxWillem II 1-1 Ajax |
| 5 | Sun 10 Jan 2021 | 431-2 v VVV VenloVVV Venlo 2-1 Willem II |
| 6 | Sun 17 Jan 2021 | 43 1-1 v RKC WaalwijkRKC Waalwijk 1-1 Willem II |
| 7 | Thu 28 Jan 2021 | 431-3 v AjaxAjax 3-1 Willem II |
| 8 | Sun 31 Jan 2021 | 432-0 v FC EmmenWillem II 2-0 FC Emmen |
| 9 | Sun 14 Feb 2021 | 430-5 v FeyenoordFeyenoord 5-0 Willem II |
| 10 | Fri 19 Feb 2021 | 430-6 v FC UtrechtWillem II 0-6 FC Utrecht |
| 11 | Wed 24 Feb 2021 | 431-1 v ADO Den HaagWillem II 1-1 ADO Den Haag |
| 12 | Sun 28 Feb 2021 | 432-0 v Sparta RotterdamSparta Rotterdam 0-2 Willem II |
| 13 | Sat 6 Mar 2021 | 431-1 v FC TwenteFC Twente 1-1 Willem II |
| 14 | Sat 13 Mar 2021 | 433-1 v sc HeerenveenWillem II 3-1 sc Heerenveen |
| 15 | Sun 21 Mar 2021 | 43 0-0 v VitesseVitesse 0-0 Willem II |
| 16 | Sat 3 Apr 2021 | 430-1 v AZ AlkmaarWillem II 0-1 AZ Alkmaar |
| 17 | Fri 23 Apr 2021 | 431-0 v RKC WaalwijkWillem II 1-0 RKC Waalwijk |
| 18 | Sat 1 May 2021 | 432-3 v FC UtrechtFC Utrecht 3-2 Willem II |
| 19 | Sun 9 May 2021 | 430-2 v PSV EindhovenWillem II 0-2 PSV Eindhoven |
| 20 | Sun 16 May 2021 | 432-1 v Fortuna SittardWillem II 2-1 Fortuna Sittard |
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