| 1 | Fri 25 Sep 2020 | 63-1 v FC GroningenFC Twente 3-1 FC Groningen |
| 2 | Sat 3 Oct 2020 | 61-1 v FC EmmenFC Twente 1-1 FC Emmen |
| 3 | Sat 17 Oct 2020 | 63-0 v Willem IIWillem II 0-3 FC Twente |
| 4 | Sat 24 Oct 2020 | 61-2 v FC UtrechtFC Utrecht 2-1 FC Twente |
| 5 | Sat 31 Oct 2020 | 65-1 v PEC ZwolleFC Twente 5-1 PEC Zwolle |
| 6 | Sat 7 Nov 2020 | 64-2 v ADO Den HaagADO Den Haag 2-4 FC Twente |
| 7 | Sun 22 Nov 2020 | 61-1 v PSV EindhovenFC Twente 1-1 PSV Eindhoven |
| 8 | Fri 27 Nov 2020 | 60-2 v RKC WaalwijkFC Twente 0-2 RKC Waalwijk |
| 9 | Sat 5 Dec 2020 | 62-1 v AjaxAjax 1-2 FC Twente |
| 10 | Sun 13 Dec 2020 | 61-3 v AZ AlkmaarFC Twente 1-3 AZ Alkmaar |
| 11 | Sat 19 Dec 2020 | 62-1 v VVV VenloVVV Venlo 1-2 FC Twente |
| 12 | Tue 22 Dec 2020 | 60-2 v Sparta RotterdamFC Twente 0-2 Sparta Rotterdam |
| 13 | Sun 17 Jan 2021 | 62-2 v FC GroningenFC Groningen 2-2 FC Twente |
| 14 | Sat 13 Mar 2021 | 61-4 v AZ AlkmaarAZ Alkmaar 4-1 FC Twente |
| 15 | Fri 19 Mar 2021 | 60-0 v sc Heerenveensc Heerenveen 0-0 FC Twente |
| 16 | Sat 1 May 2021 | 6 0-3 v Fortuna SittardFortuna Sittard 3-0 FC Twente |
| 17 | Sat 8 May 2021 | 61-1 v Heracles AlmeloFC Twente 1-1 Heracles Almelo |
| 18 | Thu 13 May 2021 | 61-2 v RKC WaalwijkRKC Waalwijk 2-1 FC Twente |
| 19 | Sun 16 May 2021 | 63-2 v ADO Den HaagFC Twente 3-2 ADO Den Haag |
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