| 1 | Sat 14 Aug 2021 | 20-4 v 1899 HoffenheimFC Augsburg 0-4 1899 Hoffenheim | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 2 0-0 v Eintracht FrankfurtEintracht Frankfurt 0-0 FC Augsburg | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 21-4 v Bayer 04 LeverkusenFC Augsburg 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 20-0 v 1. FC Union Berlin1. FC Union Berlin 0-0 FC Augsburg | German Bundesliga |
| 5 | Sat 18 Sep 2021 | 21-0 v Borussia MönchengladbachFC Augsburg 1-0 Borussia Mönchengladbach | German Bundesliga |
| 6 | Sun 26 Sep 2021 | 20-3 v SC FreiburgSC Freiburg 3-0 FC Augsburg | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 21-2 v Borussia DortmundBorussia Dortmund 2-1 FC Augsburg | German Bundesliga |
| 8 | Sun 17 Oct 2021 | 21-1 v Arminia BielefeldFC Augsburg 1-1 Arminia Bielefeld | German Bundesliga |
| 9 | Fri 22 Oct 2021 | 21-4 v Mainz 05Mainz 05 4-1 FC Augsburg | German Bundesliga |
| 10 | Sun 31 Oct 2021 | 24-1 v VfB StuttgartFC Augsburg 4-1 VfB Stuttgart | German Bundesliga |
| 11 | Sat 6 Nov 2021 | 20-1 v VfL WolfsburgVfL Wolfsburg 1-0 FC Augsburg | German Bundesliga |
| 12 | Fri 19 Nov 2021 | 22-1 v Bayern MunichFC Augsburg 2-1 Bayern Munich | German Bundesliga |
| 13 | Sat 27 Nov 2021 | 21-1 v Hertha BerlinHertha Berlin 1-1 FC Augsburg | German Bundesliga |
| 14 | Sat 4 Dec 2021 | 22-3 v VfL BochumFC Augsburg 2-3 VfL Bochum | German Bundesliga |
| 15 | Fri 10 Dec 2021 | 22-0 v 1. FC Köln1. FC Köln 0-2 FC Augsburg | German Bundesliga |
| 16 | Wed 15 Dec 2021 | 21-1 v RB LeipzigFC Augsburg 1-1 RB Leipzig | German Bundesliga |
| 17 | Sat 18 Dec 2021 | 20-0 v Greuther FürthGreuther Fürth 0-0 FC Augsburg | German Bundesliga |
| 18 | Sat 8 Jan 2022 | 21-3 v 1899 Hoffenheim1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 19 | Sun 16 Jan 2022 | 21-1 v Eintracht FrankfurtFC Augsburg 1-1 Eintracht Frankfurt | German Bundesliga |
| 20 | Sat 22 Jan 2022 | 21-5 v Bayer 04 LeverkusenBayer 04 Leverkusen 5-1 FC Augsburg | German Bundesliga |
| 21 | Sun 3 Apr 2022 | 23-0 v VfL WolfsburgFC Augsburg 3-0 VfL Wolfsburg | German Bundesliga |
| 22 | Wed 6 Apr 2022 | 2 2-1 v Mainz 05FC Augsburg 2-1 Mainz 05 | German Bundesliga |
| 23 | Sat 9 Apr 2022 | 20-1 v Bayern MunichBayern Munich 1-0 FC Augsburg | German Bundesliga |
| 24 | Sat 16 Apr 2022 | 2 0-1 v Hertha BerlinFC Augsburg 0-1 Hertha Berlin | German Bundesliga |
| 25 | Sun 24 Apr 2022 | 22-0 v VfL BochumVfL Bochum 0-2 FC Augsburg | German Bundesliga |
| 26 | Sat 30 Apr 2022 | 21-4 v 1. FC KölnFC Augsburg 1-4 1. FC Köln | German Bundesliga |
| 27 | Sun 8 May 2022 | 20-4 v RB LeipzigRB Leipzig 4-0 FC Augsburg | German Bundesliga |
| 28 | Sat 14 May 2022 | 22-1 v Greuther FürthFC Augsburg 2-1 Greuther Fürth | German Bundesliga |
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