| 1 | Sat 28 Nov 2020 | 431-4 v Borussia MönchengladbachBorussia Mönchengladbach 4-1 FC Schalke 04 | German Bundesliga |
| 2 | Sun 6 Dec 2020 | 43 0-3 v Bayer 04 LeverkusenFC Schalke 04 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 3 | Wed 16 Dec 2020 | 430-2 v SC FreiburgFC Schalke 04 0-2 SC Freiburg | German Bundesliga |
| 4 | Sat 2 Jan 2021 | 43 0-3 v Hertha BerlinHertha Berlin 3-0 FC Schalke 04 | German Bundesliga |
| 5 | Sat 9 Jan 2021 | 434-0 v 1899 HoffenheimFC Schalke 04 4-0 1899 Hoffenheim | German Bundesliga |
| 6 | Sun 17 Jan 2021 | 431-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 FC Schalke 04 | German Bundesliga |
| 7 | Wed 20 Jan 2021 | 431-2 v 1. FC KölnFC Schalke 04 1-2 1. FC Köln | German Bundesliga |
| 8 | Sun 24 Jan 2021 | 430-4 v Bayern MunichFC Schalke 04 0-4 Bayern Munich | German Bundesliga |
| 9 | Sat 30 Jan 2021 | 431-1 v Werder BremenWerder Bremen 1-1 FC Schalke 04 | German Bundesliga |
| 10 | Sat 6 Feb 2021 | 430-3 v RB LeipzigFC Schalke 04 0-3 RB Leipzig | German Bundesliga |
| 11 | Sat 13 Feb 2021 | 430-0 v 1. FC Union Berlin1. FC Union Berlin 0-0 FC Schalke 04 | German Bundesliga |
| 12 | Sat 20 Feb 2021 | 43 0-4 v Borussia DortmundFC Schalke 04 0-4 Borussia Dortmund | German Bundesliga |
| 13 | Sat 27 Feb 2021 | 431-5 v VfB StuttgartVfB Stuttgart 5-1 FC Schalke 04 | German Bundesliga |
| 14 | Fri 5 Mar 2021 | 430-0 v Mainz 05FC Schalke 04 0-0 Mainz 05 | German Bundesliga |
| 15 | Sat 13 Mar 2021 | 430-5 v VfL WolfsburgVfL Wolfsburg 5-0 FC Schalke 04 | German Bundesliga |
| 16 | Sat 20 Mar 2021 | 430-3 v Borussia MönchengladbachFC Schalke 04 0-3 Borussia Mönchengladbach | German Bundesliga |
| 17 | Sun 11 Apr 2021 | 431-0 v FC AugsburgFC Schalke 04 1-0 FC Augsburg | German Bundesliga |
| 18 | Sat 17 Apr 2021 | 430-4 v SC FreiburgSC Freiburg 4-0 FC Schalke 04 | German Bundesliga |
| 19 | Sat 8 May 2021 | 432-4 v 1899 Hoffenheim1899 Hoffenheim 4-2 FC Schalke 04 | German Bundesliga |
| 20 | Wed 12 May 2021 | 431-2 v Hertha BerlinFC Schalke 04 1-2 Hertha Berlin | German Bundesliga |
| 21 | Sat 15 May 2021 | 434-3 v Eintracht FrankfurtFC Schalke 04 4-3 Eintracht Frankfurt | German Bundesliga |
| 22 | Sat 22 May 2021 | 430-1 v 1. FC Köln1. FC Köln 1-0 FC Schalke 04 | German Bundesliga |
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