| 1 | Sat 10 Aug | 52-1 v NEC NijmegenNEC Nijmegen 1-2 FC Twente | Dutch Eredivisie |
| 2 | Tue 13 Aug | 53-3 v SV Red Bull SalzburgFC Twente 3-3 SV Red Bull Salzburg | UEFA Champions League Third Qualifying Round |
| 3 | Sat 17 Aug | 51-1 v Sparta RotterdamFC Twente 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sun 1 Sep | 51-2 v FC UtrechtFC Utrecht 2-1 FC Twente | Dutch Eredivisie |
| 5 | Tue 17 Sep | 52-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 6 | Sun 22 Sep | 55-0 v Almere CityAlmere City 0-5 FC Twente | Dutch Eredivisie |
| 7 | Sun 29 Sep | 51-0 v NAC BredaFC Twente 1-0 NAC Breda | Dutch Eredivisie |
| 8 | Sun 6 Oct | 51-2 v FeyenoordFeyenoord 2-1 FC Twente | Dutch Eredivisie |
| 9 | Sat 19 Oct | 52-2 v RKC WaalwijkRKC Waalwijk 2-2 FC Twente | Dutch Eredivisie |
| 10 | Thu 24 Oct | 50-2 v LazioFC Twente 0-2 Lazio | UEFA Europa League Matchday 3 |
| 11 | Sat 2 Nov | 51-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 12 | Thu 7 Nov | 52-2 v NiceNice 2-2 FC Twente | UEFA Europa League Matchday 4 |
| 13 | Sun 10 Nov | 52-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 14 | Thu 28 Nov | 50-1 v Union Saint-GilloiseFC Twente 0-1 Union Saint-Gilloise | UEFA Europa League Matchday 5 |
| 15 | Sun 1 Dec | 53-2 v Go Ahead EaglesFC Twente 3-2 Go Ahead Eagles | Dutch Eredivisie |
| 16 | Fri 6 Dec | 51-6 v PSV EindhovenPSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 17 | Sat 21 Dec | 5 0-1 v AZ AlkmaarAZ Alkmaar 1-0 FC Twente | Dutch Eredivisie |
| 18 | Sun 12 Jan | 56-2 v Willem IIFC Twente 6-2 Willem II | Dutch Eredivisie |
| 19 | Sun 19 Jan | 51-2 v NAC BredaNAC Breda 2-1 FC Twente | Dutch Eredivisie |
| 20 | Thu 30 Jan | 51-0 v BeşiktaşFC Twente 1-0 Beşiktaş | UEFA Europa League Matchday 8 |
| 21 | Sun 2 Feb | 5 2-2 v Go Ahead EaglesGo Ahead Eagles 2-2 FC Twente | Dutch Eredivisie |
| 22 | Sun 9 Feb | 5 3-3 v sc Heerenveensc Heerenveen 3-3 FC Twente | Dutch Eredivisie |
| 23 | Thu 13 Feb | 52-1 v FK Bodø/GlimtFC Twente 2-1 FK Bodø/Glimt | UEFA Europa League Knockout Round |
| 24 | Sun 16 Feb | 52-0 v RKC WaalwijkFC Twente 2-0 RKC Waalwijk | Dutch Eredivisie |
| 25 | Thu 20 Feb | 52-5 v FK Bodø/GlimtFK Bodø/Glimt 5-2 FC Twente | UEFA Europa League Knockout Round |
| 26 | Sun 23 Feb | 52-0 v NEC NijmegenFC Twente 2-0 NEC Nijmegen | Dutch Eredivisie |
| 27 | Sat 1 Mar | 51-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 28 | Sun 9 Mar | 51-0 v Almere CityFC Twente 1-0 Almere City | Dutch Eredivisie |
| 29 | Sun 16 Mar | 52-6 v FeyenoordFC Twente 2-6 Feyenoord | Dutch Eredivisie |
| 30 | Sun 30 Mar | 51-2 v Heracles AlmeloHeracles Almelo 2-1 FC Twente | Dutch Eredivisie |
| 31 | Sat 5 Apr | 51-1 v Fortuna SittardFC Twente 1-1 Fortuna Sittard | Dutch Eredivisie |
| 32 | Sun 13 Apr | 51-1 v PEC ZwollePEC Zwolle 1-1 FC Twente | Dutch Eredivisie |
| 33 | Thu 24 Apr | 51-3 v PSV EindhovenFC Twente 1-3 PSV Eindhoven | Dutch Eredivisie |
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