| 1 | Tue 6 Aug | 411-2 v SV Red Bull SalzburgSV Red Bull Salzburg 2-1 FC Twente | UEFA Champions League Third Qualifying Round |
| 2 | Tue 17 Sep | 412-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 3 | Wed 25 Sep | 411-1 v Manchester UnitedManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 4 | Sun 29 Sep | 41 1-0 v NAC BredaFC Twente 1-0 NAC Breda | Dutch Eredivisie |
| 5 | Sun 6 Oct | 411-2 v FeyenoordFeyenoord 2-1 FC Twente | Dutch Eredivisie |
| 6 | Thu 24 Oct | 410-2 v LazioFC Twente 0-2 Lazio | UEFA Europa League Matchday 3 |
| 7 | Sat 2 Nov | 411-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 8 | Thu 7 Nov | 412-2 v NiceNice 2-2 FC Twente | UEFA Europa League Matchday 4 |
| 9 | Sun 10 Nov | 41 2-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 10 | Sat 23 Nov | 412-1 v Fortuna SittardFortuna Sittard 1-2 FC Twente | Dutch Eredivisie |
| 11 | Thu 28 Nov | 410-1 v Union Saint-GilloiseFC Twente 0-1 Union Saint-Gilloise | UEFA Europa League Matchday 5 |
| 12 | Sat 21 Dec | 410-1 v AZ AlkmaarAZ Alkmaar 1-0 FC Twente | Dutch Eredivisie |
| 13 | Thu 23 Jan | 41 3-2 v Malmö FFMalmö FF 2-3 FC Twente | UEFA Europa League Matchday 7 |
| 14 | Thu 30 Jan | 411-0 v BeşiktaşFC Twente 1-0 Beşiktaş | UEFA Europa League Matchday 8 |
| 15 | Sun 2 Feb | 412-2 v Go Ahead EaglesGo Ahead Eagles 2-2 FC Twente | Dutch Eredivisie |
| 16 | Sun 23 Feb | 412-0 v NEC NijmegenFC Twente 2-0 NEC Nijmegen | Dutch Eredivisie |
| 17 | Sun 9 Mar | 411-0 v Almere CityFC Twente 1-0 Almere City | Dutch Eredivisie |
| 18 | Sun 16 Mar | 412-6 v FeyenoordFC Twente 2-6 Feyenoord | Dutch Eredivisie |
| 19 | Sun 13 Apr | 411-1 v PEC ZwollePEC Zwolle 1-1 FC Twente | Dutch Eredivisie |
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