| 1 | 14/8/2021 | 51-2 v Fortuna SittardFortuna Sittard 2-1 FC Twente | Dutch Eredivisie |
| 2 | 22/8/2021 | 51-1 v AjaxFC Twente 1-1 Ajax | Dutch Eredivisie |
| 3 | 19/9/2021 | 54-1 v VitesseVitesse 1-4 FC Twente | Dutch Eredivisie |
| 4 | 23/9/2021 | 53-1 v AZ AlkmaarFC Twente 3-1 AZ Alkmaar | Dutch Eredivisie |
| 5 | 26/9/2021 | 53-2 v sc Heerenveensc Heerenveen 2-3 FC Twente | Dutch Eredivisie |
| 6 | 1/10/2021 | 51-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 7 | 17/10/2021 | 51-1 v Willem IIFC Twente 1-1 Willem II | Dutch Eredivisie |
| 8 | 24/10/2021 | 51-2 v NEC NijmegenFC Twente 1-2 NEC Nijmegen | Dutch Eredivisie |
| 9 | 30/10/2021 | 52-5 v PSV EindhovenPSV Eindhoven 5-2 FC Twente | Dutch Eredivisie |
| 10 | 5/11/2021 | 51-0 v Heracles AlmeloFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 11 | 20/11/2021 | 51-0 v Sparta RotterdamSparta Rotterdam 0-1 FC Twente | Dutch Eredivisie |
| 12 | 28/11/2021 | 50-0 v FeyenoordFC Twente 0-0 Feyenoord | Dutch Eredivisie |
| 13 | 5/12/2021 | 52-1 v Go Ahead EaglesGo Ahead Eagles 1-2 FC Twente | Dutch Eredivisie |
| 14 | 12/12/2021 | 52-1 v RKC WaalwijkFC Twente 2-1 RKC Waalwijk | Dutch Eredivisie |
| 15 | 18/12/2021 | 53-1 v PEC ZwollePEC Zwolle 1-3 FC Twente | Dutch Eredivisie |
| 16 | 22/12/2021 | 51-1 v FC UtrechtFC Utrecht 1-1 FC Twente | Dutch Eredivisie |
| 17 | 15/1/2022 | 52-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 18 | 22/1/2022 | 51-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
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