| 1 | Wed 25 Sep | 31-1 v Manchester UnitedManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 2 | Sun 29 Sep | 31-0 v NAC BredaFC Twente 1-0 NAC Breda | Dutch Eredivisie |
| 3 | Sun 27 Oct | 35-0 v Heracles AlmeloFC Twente 5-0 Heracles Almelo | Dutch Eredivisie |
| 4 | Sat 2 Nov | 31-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 5 | Thu 7 Nov | 32-2 v NiceNice 2-2 FC Twente | UEFA Europa League Matchday 4 |
| 6 | Sun 10 Nov | 32-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 7 | Thu 28 Nov | 30-1 v Union Saint-GilloiseFC Twente 0-1 Union Saint-Gilloise | UEFA Europa League Matchday 5 |
| 8 | Sun 1 Dec | 33-2 v Go Ahead EaglesFC Twente 3-2 Go Ahead Eagles | Dutch Eredivisie |
| 9 | Fri 6 Dec | 31-6 v PSV EindhovenPSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 10 | Thu 12 Dec | 30-0 v OlympiakosOlympiakos 0-0 FC Twente | UEFA Europa League Matchday 6 |
| 11 | Sun 15 Dec | 32-0 v FC GroningenFC Twente 2-0 FC Groningen | Dutch Eredivisie |
| 12 | Sat 21 Dec | 3 0-1 v AZ AlkmaarAZ Alkmaar 1-0 FC Twente | Dutch Eredivisie |
| 13 | Sun 12 Jan | 36-2 v Willem IIFC Twente 6-2 Willem II | Dutch Eredivisie |
| 14 | Sun 19 Jan | 3 1-2 v NAC BredaNAC Breda 2-1 FC Twente | Dutch Eredivisie |
| 15 | Thu 23 Jan | 33-2 v Malmö FFMalmö FF 2-3 FC Twente | UEFA Europa League Matchday 7 |
| 16 | Thu 30 Jan | 31-0 v BeşiktaşFC Twente 1-0 Beşiktaş | UEFA Europa League Matchday 8 |
| 17 | Sun 2 Feb | 32-2 v Go Ahead EaglesGo Ahead Eagles 2-2 FC Twente | Dutch Eredivisie |
| 18 | Sun 9 Feb | 33-3 v sc Heerenveensc Heerenveen 3-3 FC Twente | Dutch Eredivisie |
| 19 | Thu 13 Feb | 3 2-1 v FK Bodø/GlimtFC Twente 2-1 FK Bodø/Glimt | UEFA Europa League Knockout Round |
| 20 | Sun 16 Feb | 32-0 v RKC WaalwijkFC Twente 2-0 RKC Waalwijk | Dutch Eredivisie |
| 21 | Thu 20 Feb | 32-5 v FK Bodø/GlimtFK Bodø/Glimt 5-2 FC Twente | UEFA Europa League Knockout Round |
| 22 | Sun 23 Feb | 32-0 v NEC NijmegenFC Twente 2-0 NEC Nijmegen | Dutch Eredivisie |
| 23 | Sat 1 Mar | 31-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 24 | Sun 9 Mar | 31-0 v Almere CityFC Twente 1-0 Almere City | Dutch Eredivisie |
| 25 | Sun 16 Mar | 32-6 v FeyenoordFC Twente 2-6 Feyenoord | Dutch Eredivisie |
| 26 | Sun 30 Mar | 3 1-2 v Heracles AlmeloHeracles Almelo 2-1 FC Twente | Dutch Eredivisie |
| 27 | Sat 5 Apr | 31-1 v Fortuna SittardFC Twente 1-1 Fortuna Sittard | Dutch Eredivisie |
| 28 | Thu 24 Apr | 31-3 v PSV EindhovenFC Twente 1-3 PSV Eindhoven | Dutch Eredivisie |
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