| 1 | Thu 30 Jul | 72-2 v Ferencvárosi TCFerencvárosi TC 2-2 FC Twente | UEFA Europa League Second Qualifying Round |
| 2 | Thu 6 Aug | 76-0 v Dunajská StredaFC Twente 6-0 Dunajská Streda | UEFA Conference League Third Qualifying Round |
| 3 | Sun 9 Aug | 70-1 v sc Heerenveensc Heerenveen 1-0 FC Twente | Dutch Eredivisie |
| 4 | Thu 13 Aug | 73-3 v Dunajská StredaDunajská Streda 3-3 FC Twente | UEFA Conference League Third Qualifying Round |
| 5 | Sun 16 Aug | 73-1 v PEC ZwolleFC Twente 3-1 PEC Zwolle | Dutch Eredivisie |
| 6 | Thu 20 Aug | 70-1 v FK QarabağFC Twente 0-1 FK Qarabağ | UEFA Conference League |
| 7 | Thu 27 Aug | 74-1 v FK QarabağFK Qarabağ 1-4 FC Twente | UEFA Conference League |
| 8 | Sun 30 Aug | 74-1 v SC CambuurSC Cambuur 1-4 FC Twente | Dutch Eredivisie |
| 9 | Sun 6 Sep | 72-2 v FC GroningenFC Groningen 2-2 FC Twente | Dutch Eredivisie |
| 10 | Wed 9 Sep | 71-0 v TelstarFC Twente 1-0 Telstar | Dutch Eredivisie |
| 11 | Sat 12 Sep | 72-0 v ADO Den HaagFC Twente 2-0 ADO Den Haag | Dutch Eredivisie |
| 12 | Sun 20 Sep | 73-2 v PSV EindhovenFC Twente 3-2 PSV Eindhoven | Dutch Eredivisie |
| 13 | Sat 10 Oct | 71-1 v Fortuna SittardFortuna Sittard 1-1 FC Twente | Dutch Eredivisie |
| 14 | Thu 15 Oct | 71-0 v FC ThunFC Twente 1-0 FC Thun | UEFA Conference League Matchday 1 |
| 15 | Sun 18 Oct | 71-2 v FC UtrechtFC Twente 1-2 FC Utrecht | Dutch Eredivisie |
| 16 | Thu 22 Oct | 74-1 v Lincoln Red ImpsLincoln Red Imps 1-4 FC Twente | UEFA Conference League Matchday 2 |
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