| 1 | Tue 6 Aug | 41-2 v SV Red Bull SalzburgSV Red Bull Salzburg 2-1 FC Twente | UEFA Champions League Third Qualifying Round |
| 2 | Sat 10 Aug | 42-1 v NEC NijmegenNEC Nijmegen 1-2 FC Twente | Dutch Eredivisie |
| 3 | Tue 13 Aug | 43-3 v SV Red Bull SalzburgFC Twente 3-3 SV Red Bull Salzburg | UEFA Champions League Third Qualifying Round |
| 4 | Sat 17 Aug | 41-1 v Sparta RotterdamFC Twente 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 5 | Sun 1 Sep | 41-2 v FC UtrechtFC Utrecht 2-1 FC Twente | Dutch Eredivisie |
| 6 | Wed 25 Sep | 41-1 v Manchester UnitedManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 7 | Thu 3 Oct | 41-1 v FenerbahçeFC Twente 1-1 Fenerbahçe | UEFA Europa League Matchday 2 |
| 8 | Sun 6 Oct | 41-2 v FeyenoordFeyenoord 2-1 FC Twente | Dutch Eredivisie |
| 9 | Sun 27 Oct | 45-0 v Heracles AlmeloFC Twente 5-0 Heracles Almelo | Dutch Eredivisie |
| 10 | Thu 7 Nov | 42-2 v NiceNice 2-2 FC Twente | UEFA Europa League Matchday 4 |
| 11 | Sun 10 Nov | 42-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 12 | Thu 12 Dec | 40-0 v OlympiakosOlympiakos 0-0 FC Twente | UEFA Europa League Matchday 6 |
| 13 | Sun 15 Dec | 42-0 v FC GroningenFC Twente 2-0 FC Groningen | Dutch Eredivisie |
| 14 | Sun 12 Jan | 46-2 v Willem IIFC Twente 6-2 Willem II | Dutch Eredivisie |
| 15 | Sun 19 Jan | 41-2 v NAC BredaNAC Breda 2-1 FC Twente | Dutch Eredivisie |
| 16 | Thu 30 Jan | 41-0 v BeşiktaşFC Twente 1-0 Beşiktaş | UEFA Europa League Matchday 8 |
| 17 | Sun 2 Feb | 42-2 v Go Ahead EaglesGo Ahead Eagles 2-2 FC Twente | Dutch Eredivisie |
| 18 | Sun 9 Feb | 43-3 v sc Heerenveensc Heerenveen 3-3 FC Twente | Dutch Eredivisie |
| 19 | Sun 16 Feb | 42-0 v RKC WaalwijkFC Twente 2-0 RKC Waalwijk | Dutch Eredivisie |
| 20 | Thu 20 Feb | 42-5 v FK Bodø/GlimtFK Bodø/Glimt 5-2 FC Twente | UEFA Europa League Knockout Round |
| 21 | Sun 23 Feb | 42-0 v NEC NijmegenFC Twente 2-0 NEC Nijmegen | Dutch Eredivisie |
| 22 | Sat 1 Mar | 41-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 23 | Sun 9 Mar | 41-0 v Almere CityFC Twente 1-0 Almere City | Dutch Eredivisie |
| 24 | Sun 16 Mar | 42-6 v FeyenoordFC Twente 2-6 Feyenoord | Dutch Eredivisie |
| 25 | Sun 30 Mar | 41-2 v Heracles AlmeloHeracles Almelo 2-1 FC Twente | Dutch Eredivisie |
| 26 | Sat 5 Apr | 41-1 v Fortuna SittardFC Twente 1-1 Fortuna Sittard | Dutch Eredivisie |
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