| 1 | Thu 23 Jul | 61-2 v Ferencvárosi TCFC Twente 1-2 Ferencvárosi TC | UEFA Europa League Second Qualifying Round |
| 2 | Thu 30 Jul | 62-2 v Ferencvárosi TCFerencvárosi TC 2-2 FC Twente | UEFA Europa League Second Qualifying Round |
| 3 | Thu 6 Aug | 66-0 v Dunajská StredaFC Twente 6-0 Dunajská Streda | UEFA Conference League Third Qualifying Round |
| 4 | Sun 9 Aug | 60-1 v sc Heerenveensc Heerenveen 1-0 FC Twente | Dutch Eredivisie |
| 5 | Thu 13 Aug | 63-3 v Dunajská StredaDunajská Streda 3-3 FC Twente | UEFA Conference League Third Qualifying Round |
| 6 | Sun 16 Aug | 63-1 v PEC ZwolleFC Twente 3-1 PEC Zwolle | Dutch Eredivisie |
| 7 | Thu 20 Aug | 6 0-1 v FK QarabağFC Twente 0-1 FK Qarabağ | UEFA Conference League |
| 8 | Thu 27 Aug | 6 4-1 v FK QarabağFK Qarabağ 1-4 FC Twente | UEFA Conference League |
| 9 | Sun 30 Aug | 64-1 v SC CambuurSC Cambuur 1-4 FC Twente | Dutch Eredivisie |
| 10 | Sun 6 Sep | 6 2-2 v FC GroningenFC Groningen 2-2 FC Twente | Dutch Eredivisie |
| 11 | Wed 9 Sep | 61-0 v TelstarFC Twente 1-0 Telstar | Dutch Eredivisie |
| 12 | Sat 12 Sep | 62-0 v ADO Den HaagFC Twente 2-0 ADO Den Haag | Dutch Eredivisie |
| 13 | Sun 20 Sep | 63-2 v PSV EindhovenFC Twente 3-2 PSV Eindhoven | Dutch Eredivisie |
| 14 | Sat 10 Oct | 61-1 v Fortuna SittardFortuna Sittard 1-1 FC Twente | Dutch Eredivisie |
| 15 | Thu 15 Oct | 61-0 v FC ThunFC Twente 1-0 FC Thun | UEFA Conference League Matchday 1 |
| 16 | Sun 18 Oct | 61-2 v FC UtrechtFC Twente 1-2 FC Utrecht | Dutch Eredivisie |
| 17 | Thu 22 Oct | 64-1 v Lincoln Red ImpsLincoln Red Imps 1-4 FC Twente | UEFA Conference League Matchday 2 |
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