| 1 | Tue 6 Aug | 81-2 v SV Red Bull SalzburgSV Red Bull Salzburg 2-1 FC Twente | UEFA Champions League Third Qualifying Round |
| 2 | Sat 10 Aug | 82-1 v NEC NijmegenNEC Nijmegen 1-2 FC Twente | Dutch Eredivisie |
| 3 | Sat 17 Aug | 81-1 v Sparta RotterdamFC Twente 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sun 1 Sep | 81-2 v FC UtrechtFC Utrecht 2-1 FC Twente | Dutch Eredivisie |
| 5 | Sat 14 Sep | 81-1 v PEC ZwolleFC Twente 1-1 PEC Zwolle | Dutch Eredivisie |
| 6 | Tue 17 Sep | 8 2-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 7 | Sun 22 Sep | 85-0 v Almere CityAlmere City 0-5 FC Twente | Dutch Eredivisie |
| 8 | Wed 25 Sep | 81-1 v Manchester UnitedManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 9 | Sun 29 Sep | 81-0 v NAC BredaFC Twente 1-0 NAC Breda | Dutch Eredivisie |
| 10 | Thu 3 Oct | 81-1 v FenerbahçeFC Twente 1-1 Fenerbahçe | UEFA Europa League Matchday 2 |
| 11 | Sun 6 Oct | 81-2 v FeyenoordFeyenoord 2-1 FC Twente | Dutch Eredivisie |
| 12 | Sat 19 Oct | 8 2-2 v RKC WaalwijkRKC Waalwijk 2-2 FC Twente | Dutch Eredivisie |
| 13 | Thu 24 Oct | 80-2 v LazioFC Twente 0-2 Lazio | UEFA Europa League Matchday 3 |
| 14 | Sun 27 Oct | 85-0 v Heracles AlmeloFC Twente 5-0 Heracles Almelo | Dutch Eredivisie |
| 15 | Sat 2 Nov | 81-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 16 | Thu 7 Nov | 82-2 v NiceNice 2-2 FC Twente | UEFA Europa League Matchday 4 |
| 17 | Sun 10 Nov | 82-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 18 | Sat 23 Nov | 82-1 v Fortuna SittardFortuna Sittard 1-2 FC Twente | Dutch Eredivisie |
| 19 | Thu 28 Nov | 8 0-1 v Union Saint-GilloiseFC Twente 0-1 Union Saint-Gilloise | UEFA Europa League Matchday 5 |
| 20 | Sun 1 Dec | 83-2 v Go Ahead EaglesFC Twente 3-2 Go Ahead Eagles | Dutch Eredivisie |
| 21 | Fri 6 Dec | 81-6 v PSV EindhovenPSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 22 | Thu 12 Dec | 8 0-0 v OlympiakosOlympiakos 0-0 FC Twente | UEFA Europa League Matchday 6 |
| 23 | Sun 15 Dec | 82-0 v FC GroningenFC Twente 2-0 FC Groningen | Dutch Eredivisie |
| 24 | Sat 21 Dec | 80-1 v AZ AlkmaarAZ Alkmaar 1-0 FC Twente | Dutch Eredivisie |
| 25 | Sun 12 Jan | 86-2 v Willem IIFC Twente 6-2 Willem II | Dutch Eredivisie |
| 26 | Sun 19 Jan | 81-2 v NAC BredaNAC Breda 2-1 FC Twente | Dutch Eredivisie |
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