| 1 | Thu 27 Jul | 41-0 v HammarbyFC Twente 1-0 Hammarby | UEFA Europa Conference League Second Qualifying Round |
| 2 | Thu 3 Aug | 41-1 v HammarbyHammarby 1-1 FC Twente | UEFA Europa Conference League Second Qualifying Round |
| 3 | Thu 10 Aug | 42-0 v FK Daugava RigaFC Twente 2-0 FK Daugava Riga | UEFA Europa Conference League Third Qualifying Round |
| 4 | Sun 13 Aug | 44-1 v Almere CityAlmere City 1-4 FC Twente | Dutch Eredivisie |
| 5 | Thu 17 Aug | 43-0 v FK Daugava RigaFK Daugava Riga 0-3 FC Twente | UEFA Europa Conference League Third Qualifying Round |
| 6 | Sun 20 Aug | 213-1 v PEC ZwolleFC Twente 3-1 PEC Zwolle | Dutch Eredivisie |
| 7 | Thu 24 Aug | 41-5 v FenerbahçeFenerbahçe 5-1 FC Twente | UEFA Europa Conference League Play-off |
| 8 | Thu 31 Aug | 4 0-1 v FenerbahçeFC Twente 0-1 Fenerbahçe | UEFA Europa Conference League Play-off |
| 9 | Sun 3 Sep | 4 2-0 v VolendamVolendam 0-2 FC Twente | Dutch Eredivisie |
| 10 | Sun 17 Sep | 43-1 v AjaxFC Twente 3-1 Ajax | Dutch Eredivisie |
| 11 | Sun 24 Sep | 40-1 v RKC WaalwijkRKC Waalwijk 1-0 FC Twente | Dutch Eredivisie |
| 12 | Wed 27 Sep | 41-0 v VitesseFC Twente 1-0 Vitesse | Dutch Eredivisie |
| 13 | Sat 30 Sep | 41-0 v sc HeerenveenFC Twente 1-0 sc Heerenveen | Dutch Eredivisie |
| 14 | Sun 8 Oct | 43-0 v Fortuna SittardFortuna Sittard 0-3 FC Twente | Dutch Eredivisie |
| 15 | Sun 22 Oct | 4 2-2 v Heracles AlmeloHeracles Almelo 2-2 FC Twente | Dutch Eredivisie |
| 16 | Sun 29 Oct | 42-1 v FeyenoordFC Twente 2-1 Feyenoord | Dutch Eredivisie |
| 17 | Sun 5 Nov | 41-1 v FC UtrechtFC Utrecht 1-1 FC Twente | Dutch Eredivisie |
| 18 | Sat 11 Nov | 43-3 v NEC NijmegenFC Twente 3-3 NEC Nijmegen | Dutch Eredivisie |
| 19 | Sat 25 Nov | 40-3 v PSV EindhovenFC Twente 0-3 PSV Eindhoven | Dutch Eredivisie |
| 20 | Sun 3 Dec | 43-1 v Go Ahead EaglesGo Ahead Eagles 1-3 FC Twente | Dutch Eredivisie |
| 21 | Fri 8 Dec | 44-2 v Excelsior RotterdamFC Twente 4-2 Excelsior Rotterdam | Dutch Eredivisie |
| 22 | Sun 17 Dec | 42-2 v Sparta RotterdamSparta Rotterdam 2-2 FC Twente | Dutch Eredivisie |
| 23 | Sat 13 Jan | 42-1 v AZ AlkmaarFC Twente 2-1 AZ Alkmaar | Dutch Eredivisie |
| 24 | Sun 28 Jan | 40-0 v FeyenoordFeyenoord 0-0 FC Twente | Dutch Eredivisie |
| 25 | Sat 3 Feb | 43-0 v RKC WaalwijkFC Twente 3-0 RKC Waalwijk | Dutch Eredivisie |
| 26 | Sat 10 Feb | 43-0 v Excelsior RotterdamExcelsior Rotterdam 0-3 FC Twente | Dutch Eredivisie |
| 27 | Sun 25 Feb | 43-0 v Go Ahead EaglesFC Twente 3-0 Go Ahead Eagles | Dutch Eredivisie |
| 28 | Sat 2 Mar | 42-1 v VitesseVitesse 1-2 FC Twente | Dutch Eredivisie |
| 29 | Sun 17 Mar | 40-1 v PSV EindhovenPSV Eindhoven 1-0 FC Twente | Dutch Eredivisie |
| 30 | Sun 31 Mar | 41-0 v Heracles AlmeloFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 31 | Wed 3 Apr | 43-3 v sc Heerenveensc Heerenveen 3-3 FC Twente | Dutch Eredivisie |
| 32 | Sat 6 Apr | 42-0 v Fortuna SittardFC Twente 2-0 Fortuna Sittard | Dutch Eredivisie |
| 33 | Sun 14 Apr | 4 1-2 v AjaxAjax 2-1 FC Twente | Dutch Eredivisie |
| 34 | Wed 24 Apr | 43-1 v Almere CityFC Twente 3-1 Almere City | Dutch Eredivisie |
| 35 | Sun 5 May | 41-2 v AZ AlkmaarAZ Alkmaar 2-1 FC Twente | Dutch Eredivisie |
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