| 1 | 14/8/2021 | 20-2 v Warrington TownWarrington Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 2 | 17/8/2021 | 63-0 v Morpeth TownFC United of Manchester 3-0 Morpeth Town | Northern Premier League - Premier Division |
| 3 | 21/8/2021 | 6 1-1 v BuxtonFC United of Manchester 1-1 Buxton | Northern Premier League - Premier Division |
| 4 | 24/8/2021 | 61-1 v South ShieldsSouth Shields 1-1 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | 28/8/2021 | 61-2 v Hyde UnitedHyde United 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 6 | 30/8/2021 | 63-0 v RadcliffeFC United of Manchester 3-0 Radcliffe | Northern Premier League - Premier Division |
| 7 | 4/9/2021 | 62-2 v BootleBootle 2-2 FC United of Manchester | Emirates FA Cup First Qualifying Round |
| 8 | 7/9/2021 | 63-2 v BootleFC United of Manchester 3-2 Bootle | Emirates FA Cup First Qualifying Round Replay |
| 9 | 11/9/2021 | 2 1-3 v Stafford RangersFC United of Manchester 1-3 Stafford Rangers | Northern Premier League - Premier Division |
| 10 | 14/9/2021 | 61-0 v Bamber BridgeFC United of Manchester 1-0 Bamber Bridge | Northern Premier League - Premier Division |
| 11 | 18/9/2021 | 61-1 v Blyth SpartansBlyth Spartans 1-1 FC United of Manchester | Emirates FA Cup Second Qualifying Round |
| 12 | 21/9/2021 | 60-2 v Blyth SpartansFC United of Manchester 0-2 Blyth Spartans | Emirates FA Cup Second Qualifying Round Replay |
| 13 | 25/9/2021 | 62-5 v Stalybridge CelticStalybridge Celtic 5-2 FC United of Manchester | Northern Premier League - Premier Division |
| 14 | 28/9/2021 | 6 6-0 v Scarborough AthleticFC United of Manchester 6-0 Scarborough Athletic | Northern Premier League - Premier Division |
| 15 | 2/10/2021 | 60-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 16 | 5/10/2021 | 6 1-0 v Basford UnitedBasford United 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 17 | 9/10/2021 | 60-2 v Nantwich TownFC United of Manchester 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 18 | 12/10/2021 | 60-1 v Lancaster CityLancaster City 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 19 | 16/10/2021 | 6 0-1 v Grantham TownFC United of Manchester 0-1 Grantham Town | Northern Premier League - Premier Division |
| 20 | 30/10/2021 | 22-0 v Runcorn LinnetsRuncorn Linnets 0-2 FC United of Manchester | Buildbase FA Trophy Third Qualifying Round |
| 21 | 6/11/2021 | 23-2 v Gainsborough TrinityFC United of Manchester 3-2 Gainsborough Trinity | Northern Premier League - Premier Division |
| 22 | 9/11/2021 | 20-1 v Whitby TownWhitby Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 23 | 13/11/2021 | 52-3 v Marske UnitedMarske United 3-2 FC United of Manchester | Buildbase FA Trophy First Round |
| 24 | 20/11/2021 | 6 1-2 v Atherton CollieriesAtherton Collieries 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 25 | 27/11/2021 | 62-0 v MickleoverFC United of Manchester 2-0 Mickleover | Northern Premier League - Premier Division |
| 26 | 11/12/2021 | 52-0 v Stafford RangersStafford Rangers 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 27 | 18/12/2021 | 52-1 v BuxtonBuxton 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 28 | 27/12/2021 | 54-3 v Ashton UnitedFC United of Manchester 4-3 Ashton United | Northern Premier League - Premier Division |
| 29 | 1/1/2022 | 53-3 v RadcliffeRadcliffe 3-3 FC United of Manchester | Northern Premier League - Premier Division |
| 30 | 15/1/2022 | 50-0 v Bamber BridgeBamber Bridge 0-0 FC United of Manchester | Northern Premier League - Premier Division |
| 31 | 22/1/2022 | 52-1 v Stalybridge CelticFC United of Manchester 2-1 Stalybridge Celtic | Northern Premier League - Premier Division |
| 32 | 25/1/2022 | 53-4 v Whitby TownFC United of Manchester 3-4 Whitby Town | Northern Premier League - Premier Division |
| 33 | 29/1/2022 | 5 2-1 v Grantham TownGrantham Town 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 34 | 5/2/2022 | 52-0 v Witton AlbionFC United of Manchester 2-0 Witton Albion | Northern Premier League - Premier Division |
| 35 | 8/2/2022 | 51-0 v Lancaster CityFC United of Manchester 1-0 Lancaster City | Northern Premier League - Premier Division |
| 36 | 12/2/2022 | 52-3 v Gainsborough TrinityGainsborough Trinity 3-2 FC United of Manchester | Northern Premier League - Premier Division |
| 37 | 15/2/2022 | 50-1 v Warrington TownFC United of Manchester 0-1 Warrington Town | Northern Premier League - Premier Division |
| 38 | 19/2/2022 | 52-2 v Scarborough AthleticScarborough Athletic 2-2 FC United of Manchester | Northern Premier League - Premier Division |
| 39 | 26/2/2022 | 21-1 v Matlock TownFC United of Manchester 1-1 Matlock Town | Northern Premier League - Premier Division |
| 40 | 12/3/2022 | 50-2 v Nantwich TownNantwich Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 41 | 19/3/2022 | 53-2 v Basford UnitedFC United of Manchester 3-2 Basford United | Northern Premier League - Premier Division |
| 42 | 2/4/2022 | 22-0 v Atherton CollieriesFC United of Manchester 2-0 Atherton Collieries | Northern Premier League - Premier Division |
| 43 | 9/4/2022 | 50-1 v Morpeth TownMorpeth Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 44 | 16/4/2022 | 50-1 v South ShieldsFC United of Manchester 0-1 South Shields | Northern Premier League - Premier Division |
| 45 | 18/4/2022 | 53-0 v Ashton UnitedAshton United 0-3 FC United of Manchester | Northern Premier League - Premier Division |
| 46 | 23/4/2022 | 50-2 v Hyde UnitedFC United of Manchester 0-2 Hyde United | Northern Premier League - Premier Division |
Football Web Pages