| 1 | Fri 28 Aug 2020 | 74-1 v DijonLyon 4-1 Dijon |
| 2 | Fri 11 Sep 2020 | 70-0 v BordeauxBordeaux 0-0 Lyon |
| 3 | Tue 15 Sep 2020 | 7 1-2 v MontpellierMontpellier 2-1 Lyon |
| 4 | Fri 18 Sep 2020 | 70-0 v NîmesLyon 0-0 Nîmes |
| 5 | Sun 4 Oct 2020 | 71-1 v MarseilleLyon 1-1 Marseille |
| 6 | Sun 18 Oct 2020 | 7 3-2 v StrasbourgStrasbourg 2-3 Lyon |
| 7 | Sun 25 Oct 2020 | 74-1 v MonacoLyon 4-1 Monaco |
| 8 | Sun 1 Nov 2020 | 7 1-1 v LilleLille 1-1 Lyon |
| 9 | Sun 8 Nov 2020 | 72-1 v Saint ÉtienneLyon 2-1 Saint Étienne |
| 10 | Sun 29 Nov 2020 | 73-0 v ReimsLyon 3-0 Reims |
| 11 | Sun 6 Dec 2020 | 73-1 v MetzMetz 1-3 Lyon |
| 12 | Sun 13 Dec 2020 | 71-0 v Paris St GermainParis St Germain 0-1 Lyon |
| 13 | Wed 16 Dec 2020 | 72-2 v BrestLyon 2-2 Brest |
| 14 | Sat 19 Dec 2020 | 74-1 v NiceNice 1-4 Lyon |
| 15 | Wed 23 Dec 2020 | 73-0 v NantesLyon 3-0 Nantes |
| 16 | Sat 9 Jan 2021 | 72-2 v RennesRennes 2-2 Lyon |
| 17 | Sun 17 Jan 2021 | 70-1 v MetzLyon 0-1 Metz |
| 18 | Sun 24 Jan 2021 | 75-0 v Saint ÉtienneSaint Étienne 0-5 Lyon |
| 19 | Fri 29 Jan 2021 | 72-1 v BordeauxLyon 2-1 Bordeaux |
| 20 | Wed 3 Feb 2021 | 71-0 v DijonDijon 0-1 Lyon |
| 21 | Sat 6 Feb 2021 | 73-0 v StrasbourgLyon 3-0 Strasbourg |
| 22 | Sat 13 Feb 2021 | 71-2 v MontpellierLyon 1-2 Montpellier |
| 23 | Fri 19 Feb 2021 | 73-2 v BrestBrest 2-3 Lyon |
| 24 | Sun 28 Feb 2021 | 71-1 v MarseilleMarseille 1-1 Lyon |
| 25 | Wed 3 Mar 2021 | 71-0 v RennesLyon 1-0 Rennes |
| 26 | Fri 12 Mar 2021 | 71-1 v ReimsReims 1-1 Lyon |
| 27 | Sun 21 Mar 2021 | 72-4 v Paris St GermainLyon 2-4 Paris St Germain |
| 28 | Sat 3 Apr 2021 | 71-1 v LensLens 1-1 Lyon |
| 29 | Sun 11 Apr 2021 | 73-0 v AngersLyon 3-0 Angers |
| 30 | Sun 18 Apr 2021 | 72-1 v NantesNantes 1-2 Lyon |
| 31 | Sun 25 Apr 2021 | 72-3 v LilleLyon 2-3 Lille |
| 32 | Sun 2 May 2021 | 73-2 v MonacoMonaco 2-3 Lyon |
| 33 | Sat 8 May 2021 | 74-1 v LorientLyon 4-1 Lorient |
| 34 | Sun 16 May 2021 | 75-2 v NîmesNîmes 2-5 Lyon |
| 35 | Sun 23 May 2021 | 72-3 v NiceLyon 2-3 Nice |
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