| 1 | Sun 18 Oct 2020 | 123-2 v StrasbourgStrasbourg 2-3 Lyon |
| 2 | Sun 25 Oct 2020 | 124-1 v MonacoLyon 4-1 Monaco |
| 3 | Sun 1 Nov 2020 | 121-1 v LilleLille 1-1 Lyon |
| 4 | Sun 8 Nov 2020 | 12 2-1 v Saint ÉtienneLyon 2-1 Saint Étienne |
| 5 | Sun 22 Nov 2020 | 121-0 v AngersAngers 0-1 Lyon |
| 6 | Sun 29 Nov 2020 | 123-0 v ReimsLyon 3-0 Reims |
| 7 | Sun 6 Dec 2020 | 123-1 v MetzMetz 1-3 Lyon |
| 8 | Sun 13 Dec 2020 | 121-0 v Paris St GermainParis St Germain 0-1 Lyon |
| 9 | Wed 16 Dec 2020 | 12 2-2 v BrestLyon 2-2 Brest |
| 10 | Sat 19 Dec 2020 | 124-1 v NiceNice 1-4 Lyon |
| 11 | Wed 23 Dec 2020 | 123-0 v NantesLyon 3-0 Nantes |
| 12 | Wed 6 Jan 2021 | 123-2 v LensLyon 3-2 Lens |
| 13 | Sat 9 Jan 2021 | 12 2-2 v RennesRennes 2-2 Lyon |
| 14 | Sun 17 Jan 2021 | 120-1 v MetzLyon 0-1 Metz |
| 15 | Fri 29 Jan 2021 | 122-1 v BordeauxLyon 2-1 Bordeaux |
| 16 | Wed 3 Feb 2021 | 121-0 v DijonDijon 0-1 Lyon |
| 17 | Sat 6 Feb 2021 | 123-0 v StrasbourgLyon 3-0 Strasbourg |
| 18 | Sat 13 Feb 2021 | 121-2 v MontpellierLyon 1-2 Montpellier |
| 19 | Fri 19 Feb 2021 | 12 3-2 v BrestBrest 2-3 Lyon |
| 20 | Sun 28 Feb 2021 | 12 1-1 v MarseilleMarseille 1-1 Lyon |
| 21 | Fri 12 Mar 2021 | 121-1 v ReimsReims 1-1 Lyon |
| 22 | Sun 21 Mar 2021 | 122-4 v Paris St GermainLyon 2-4 Paris St Germain |
| 23 | Sat 3 Apr 2021 | 121-1 v LensLens 1-1 Lyon |
| 24 | Sun 11 Apr 2021 | 123-0 v AngersLyon 3-0 Angers |
| 25 | Sun 18 Apr 2021 | 122-1 v NantesNantes 1-2 Lyon |
| 26 | Sun 25 Apr 2021 | 122-3 v LilleLyon 2-3 Lille |
| 27 | Sun 2 May 2021 | 123-2 v MonacoMonaco 2-3 Lyon |
| 28 | Sat 8 May 2021 | 124-1 v LorientLyon 4-1 Lorient |
| 29 | Sun 16 May 2021 | 125-2 v NîmesNîmes 2-5 Lyon |
| 30 | Sun 23 May 2021 | 122-3 v NiceLyon 2-3 Nice |
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