| 1 | Thu 23 Mar | 72-1 v MaltaNorth Macedonia 2-1 Malta | European Championship Qualification Group C |
| 2 | Fri 16 Jun | 72-3 v UkraineNorth Macedonia 2-3 Ukraine | European Championship Qualification Group C |
| 3 | Mon 19 Jun | 70-7 v EnglandEngland 7-0 North Macedonia | European Championship Qualification Group C |
| 4 | Sat 19 Aug | 73-1 v FrosinoneFrosinone 1-3 Napoli | Italian Serie A |
| 5 | Sun 27 Aug | 72-0 v SassuoloNapoli 2-0 Sassuolo | Italian Serie A |
| 6 | Sat 9 Sep | 71-1 v ItalyNorth Macedonia 1-1 Italy | European Championship Qualification Group C |
| 7 | Tue 12 Sep | 72-0 v MaltaMalta 0-2 North Macedonia | European Championship Qualification Group C |
| 8 | Sat 16 Sep | 7 2-2 v GenoaGenoa 2-2 Napoli | Italian Serie A |
| 9 | Wed 20 Sep | 72-1 v Sporting BragaSporting Braga 1-2 Napoli | UEFA Champions League Group C |
| 10 | Sun 24 Sep | 70-0 v BolognaBologna 0-0 Napoli | Italian Serie A |
| 11 | Wed 27 Sep | 74-1 v UdineseNapoli 4-1 Udinese | Italian Serie A |
| 12 | Tue 3 Oct | 72-3 v Real MadridNapoli 2-3 Real Madrid | UEFA Champions League Group C |
| 13 | Sat 14 Oct | 70-2 v UkraineUkraine 2-0 North Macedonia | European Championship Qualification Group C |
| 14 | Tue 17 Oct | 73-1 v ArmeniaNorth Macedonia 3-1 Armenia | International Friendly |
| 15 | Tue 24 Oct | 71-0 v 1 FC Union Berlin1 FC Union Berlin 0-1 Napoli | UEFA Champions League Group C |
| 16 | Sun 29 Oct | 72-2 v AC MilanNapoli 2-2 AC Milan | Italian Serie A |
| 17 | Sat 4 Nov | 72-0 v SalernitanaSalernitana 0-2 Napoli | Italian Serie A |
| 18 | Sun 12 Nov | 70-1 v EmpoliNapoli 0-1 Empoli | Italian Serie A |
| 19 | Fri 17 Nov | 72-5 v ItalyItaly 5-2 North Macedonia | European Championship Qualification Group C |
| 20 | Mon 20 Nov | 7 1-1 v EnglandNorth Macedonia 1-1 England | European Championship Qualification Group C |
| 21 | Sat 25 Nov | 72-1 v AtalantaAtalanta 1-2 Napoli | Italian Serie A |
| 22 | Wed 29 Nov | 72-4 v Real MadridReal Madrid 4-2 Napoli | UEFA Champions League Group C |
| 23 | Sun 3 Dec | 7 0-3 v Inter MilanNapoli 0-3 Inter Milan | Italian Serie A |
| 24 | Fri 8 Dec | 70-1 v JuventusJuventus 1-0 Napoli | Italian Serie A |
| 25 | Tue 12 Dec | 72-0 v Sporting BragaNapoli 2-0 Sporting Braga | UEFA Champions League Group C |
| 26 | Sat 13 Jan | 60-1 v Eintracht FrankfurtRB Leipzig 0-1 Eintracht Frankfurt | German Bundesliga |
| 27 | Sat 20 Jan | 62-3 v Bayer 04 LeverkusenRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 28 | Sat 27 Jan | 62-5 v VfB StuttgartVfB Stuttgart 5-2 RB Leipzig | German Bundesliga |
| 29 | Sun 4 Feb | 62-0 v 1 FC Union BerlinRB Leipzig 2-0 1 FC Union Berlin | German Bundesliga |
| 30 | Sat 10 Feb | 62-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig | German Bundesliga |
| 31 | Tue 13 Feb | 60-1 v Real MadridRB Leipzig 0-1 Real Madrid | UEFA Champions League Round of 16 |
| 32 | Sat 24 Feb | 61-2 v Bayern MunichBayern Munich 2-1 RB Leipzig | German Bundesliga |
| 33 | Sat 2 Mar | 64-1 v VfL BochumVfL Bochum 1-4 RB Leipzig | German Bundesliga |
| 34 | Wed 6 Mar | 61-1 v Real MadridReal Madrid 1-1 RB Leipzig | UEFA Champions League Round of 16 |
| 35 | Sat 9 Mar | 62-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 | German Bundesliga |
| 36 | Fri 22 Mar | 71-1 v MoldovaNorth Macedonia 1-1 Moldova | International Friendly |
| 37 | Mon 25 Mar | 7 0-1 v MontenegroMontenegro 1-0 North Macedonia | International Friendly |
| 38 | Sat 30 Mar | 60-0 v Mainz 05RB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 39 | Sat 6 Apr | 64-1 v SC FreiburgSC Freiburg 1-4 RB Leipzig | German Bundesliga |
| 40 | Sat 13 Apr | 63-0 v VfL WolfsburgRB Leipzig 3-0 VfL Wolfsburg | German Bundesliga |
| 41 | Sat 20 Apr | 62-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 RB Leipzig | German Bundesliga |
Football Web Pages