| 1 | Sun 18 Aug 2019 | 274-0 v 1. FC Union Berlin1. FC Union Berlin 0-4 RB Leipzig |
| 2 | Sun 25 Aug 2019 | 272-1 v Eintracht FrankfurtRB Leipzig 2-1 Eintracht Frankfurt |
| 3 | Fri 30 Aug 2019 | 27 3-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 RB Leipzig |
| 4 | Sat 14 Sep 2019 | 27 1-1 v Bayern MunichRB Leipzig 1-1 Bayern Munich |
| 5 | Sat 21 Sep 2019 | 27 3-0 v Werder BremenWerder Bremen 0-3 RB Leipzig |
| 6 | Sat 5 Oct 2019 | 271-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-1 RB Leipzig |
| 7 | Sat 19 Oct 2019 | 271-1 v VfL WolfsburgRB Leipzig 1-1 VfL Wolfsburg |
| 8 | Sat 2 Nov 2019 | 278-0 v Mainz 05RB Leipzig 8-0 Mainz 05 |
| 9 | Sat 9 Nov 2019 | 274-2 v Hertha BerlinHertha Berlin 2-4 RB Leipzig |
| 10 | Sat 23 Nov 2019 | 274-1 v 1. FC KölnRB Leipzig 4-1 1. FC Köln |
| 11 | Sat 30 Nov 2019 | 273-2 v SC Paderborn 07SC Paderborn 07 2-3 RB Leipzig |
| 12 | Sat 7 Dec 2019 | 27 3-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim |
| 13 | Sat 14 Dec 2019 | 273-0 v Fortuna DüsseldorfFortuna Düsseldorf 0-3 RB Leipzig |
| 14 | Tue 17 Dec 2019 | 273-3 v Borussia DortmundBorussia Dortmund 3-3 RB Leipzig |
| 15 | Sat 21 Dec 2019 | 273-1 v FC AugsburgRB Leipzig 3-1 FC Augsburg |
| 16 | Sat 18 Jan 2020 | 273-1 v 1. FC Union BerlinRB Leipzig 3-1 1. FC Union Berlin |
| 17 | Sat 25 Jan 2020 | 270-2 v Eintracht FrankfurtEintracht Frankfurt 2-0 RB Leipzig |
| 18 | Sat 1 Feb 2020 | 272-2 v Borussia MönchengladbachRB Leipzig 2-2 Borussia Mönchengladbach |
| 19 | Sat 15 Feb 2020 | 273-0 v Werder BremenRB Leipzig 3-0 Werder Bremen |
| 20 | Sat 22 Feb 2020 | 27 5-0 v FC Schalke 04FC Schalke 04 0-5 RB Leipzig |
| 21 | Sat 7 Mar 2020 | 27 0-0 v VfL WolfsburgVfL Wolfsburg 0-0 RB Leipzig |
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