| 1 | Sat 24 Aug 2019 | 3-1 v Fortuna DüsseldorfFortuna Düsseldorf 1-3 Bayer 04 Leverkusen |
| 2 | Sat 31 Aug 2019 | 0-0 v 1899 HoffenheimBayer 04 Leverkusen 0-0 1899 Hoffenheim |
| 3 | Sat 14 Sep 2019 | 0-4 v Borussia DortmundBorussia Dortmund 4-0 Bayer 04 Leverkusen |
| 4 | Sat 21 Sep 2019 | 2-0 v 1. FC Union BerlinBayer 04 Leverkusen 2-0 1. FC Union Berlin |
| 5 | Sat 28 Sep 2019 | 3-0 v FC AugsburgFC Augsburg 0-3 Bayer 04 Leverkusen |
| 6 | Sat 5 Oct 2019 | 1-1 v RB LeipzigBayer 04 Leverkusen 1-1 RB Leipzig |
| 7 | Fri 18 Oct 2019 | 0-3 v Eintracht FrankfurtEintracht Frankfurt 3-0 Bayer 04 Leverkusen |
| 8 | Sat 26 Oct 2019 | 2-2 v Werder BremenBayer 04 Leverkusen 2-2 Werder Bremen |
| 9 | Sat 2 Nov 2019 | 1-2 v Borussia MönchengladbachBayer 04 Leverkusen 1-2 Borussia Mönchengladbach |
| 10 | Sun 10 Nov 2019 | 2-0 v VfL WolfsburgVfL Wolfsburg 0-2 Bayer 04 Leverkusen |
| 11 | Sat 23 Nov 2019 | 1-1 v SC FreiburgBayer 04 Leverkusen 1-1 SC Freiburg |
| 12 | Sat 30 Nov 2019 | 2-1 v Bayern MunichBayern Munich 1-2 Bayer 04 Leverkusen |
| 13 | Sat 7 Dec 2019 | 2-1 v FC Schalke 04Bayer 04 Leverkusen 2-1 FC Schalke 04 |
| 14 | Sat 14 Dec 2019 | 0-2 v 1. FC Köln1. FC Köln 2-0 Bayer 04 Leverkusen |
| 15 | Wed 18 Dec 2019 | 0-1 v Hertha BerlinBayer 04 Leverkusen 0-1 Hertha Berlin |
| 16 | Sat 21 Dec 2019 | 1-0 v Mainz 05Mainz 05 0-1 Bayer 04 Leverkusen |
| 17 | Sun 26 Jan 2020 | 3-0 v Fortuna DüsseldorfBayer 04 Leverkusen 3-0 Fortuna Düsseldorf |
| 18 | Sat 1 Feb 2020 | 1-2 v 1899 Hoffenheim1899 Hoffenheim 2-1 Bayer 04 Leverkusen |
| 19 | Sat 15 Feb 2020 | 3-2 v 1. FC Union Berlin1. FC Union Berlin 2-3 Bayer 04 Leverkusen |
| 20 | Sun 23 Feb 2020 | 2-0 v FC AugsburgBayer 04 Leverkusen 2-0 FC Augsburg |
| 21 | Sun 1 Mar 2020 | 1-1 v RB LeipzigRB Leipzig 1-1 Bayer 04 Leverkusen |
| 22 | Sat 27 Jun 2020 | 111-0 v Mainz 05Bayer 04 Leverkusen 1-0 Mainz 05 |
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