| 1 | Sun 18 Aug 2019 | 0-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 1899 Hoffenheim |
| 2 | Sat 24 Aug 2019 | 3-2 v Werder Bremen1899 Hoffenheim 3-2 Werder Bremen |
| 3 | Sat 31 Aug 2019 | 0-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-0 1899 Hoffenheim |
| 4 | Sun 15 Sep 2019 | 0-3 v SC Freiburg1899 Hoffenheim 0-3 SC Freiburg |
| 5 | Mon 23 Sep 2019 | 1-1 v VfL WolfsburgVfL Wolfsburg 1-1 1899 Hoffenheim |
| 6 | Sat 28 Sep 2019 | 0-3 v Borussia Mönchengladbach1899 Hoffenheim 0-3 Borussia Mönchengladbach |
| 7 | Sat 5 Oct 2019 | 2-1 v Bayern MunichBayern Munich 1-2 1899 Hoffenheim |
| 8 | Sun 20 Oct 2019 | 2-0 v FC Schalke 041899 Hoffenheim 2-0 FC Schalke 04 |
| 9 | Sat 26 Oct 2019 | 3-2 v Hertha BerlinHertha Berlin 2-3 1899 Hoffenheim |
| 10 | Fri 1 Nov 2019 | 3-0 v SC Paderborn 071899 Hoffenheim 3-0 SC Paderborn 07 |
| 11 | Fri 8 Nov 2019 | 2-1 v 1. FC Köln1. FC Köln 1-2 1899 Hoffenheim |
| 12 | Sun 24 Nov 2019 | 1-5 v Mainz 051899 Hoffenheim 1-5 Mainz 05 |
| 13 | Sat 30 Nov 2019 | 1-1 v Fortuna Düsseldorf1899 Hoffenheim 1-1 Fortuna Düsseldorf |
| 14 | Fri 13 Dec 2019 | 2-4 v FC Augsburg1899 Hoffenheim 2-4 FC Augsburg |
| 15 | Tue 17 Dec 2019 | 2-0 v 1. FC Union Berlin1. FC Union Berlin 0-2 1899 Hoffenheim |
| 16 | Fri 20 Dec 2019 | 2-1 v Borussia Dortmund1899 Hoffenheim 2-1 Borussia Dortmund |
| 17 | Sat 18 Jan 2020 | 1-2 v Eintracht Frankfurt1899 Hoffenheim 1-2 Eintracht Frankfurt |
| 18 | Sun 26 Jan 2020 | 3-0 v Werder BremenWerder Bremen 0-3 1899 Hoffenheim |
| 19 | Sat 1 Feb 2020 | 2-1 v Bayer 04 Leverkusen1899 Hoffenheim 2-1 Bayer 04 Leverkusen |
| 20 | Sat 8 Feb 2020 | 0-1 v SC FreiburgSC Freiburg 1-0 1899 Hoffenheim |
| 21 | Sat 15 Feb 2020 | 2-3 v VfL Wolfsburg1899 Hoffenheim 2-3 VfL Wolfsburg |
| 22 | Sat 22 Feb 2020 | 1-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 1899 Hoffenheim |
| 23 | Sat 29 Feb 2020 | 0-6 v Bayern Munich1899 Hoffenheim 0-6 Bayern Munich |
| 24 | Sat 7 Mar 2020 | 1-1 v FC Schalke 04FC Schalke 04 1-1 1899 Hoffenheim |
| 25 | Sat 27 Jun 2020 | 164-0 v Borussia DortmundBorussia Dortmund 0-4 1899 Hoffenheim |
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