| 1 | Sat 19 Aug | 13-2 v RB LeipzigBayer 04 Leverkusen 3-2 RB Leipzig |
| 2 | Sat 26 Aug | 13-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-3 Bayer 04 Leverkusen |
| 3 | Sat 2 Sep | 15-1 v Darmstadt 98Bayer 04 Leverkusen 5-1 Darmstadt 98 |
| 4 | Fri 15 Sep | 12-2 v Bayern MunichBayern Munich 2-2 Bayer 04 Leverkusen |
| 5 | Sun 24 Sep | 14-1 v 1 FC HeidenheimBayer 04 Leverkusen 4-1 1 FC Heidenheim |
| 6 | Sat 30 Sep | 13-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen |
| 7 | Sun 8 Oct | 13-0 v 1 FC KölnBayer 04 Leverkusen 3-0 1 FC Köln |
| 8 | Sat 21 Oct | 12-1 v VfL WolfsburgVfL Wolfsburg 1-2 Bayer 04 Leverkusen |
| 9 | Sun 29 Oct | 12-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg |
| 10 | Sat 4 Nov | 1 3-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Bayer 04 Leverkusen |
| 11 | Sun 12 Nov | 14-0 v 1 FC Union BerlinBayer 04 Leverkusen 4-0 1 FC Union Berlin |
| 12 | Sat 25 Nov | 13-0 v Werder BremenWerder Bremen 0-3 Bayer 04 Leverkusen |
| 13 | Sun 3 Dec | 11-1 v Borussia DortmundBayer 04 Leverkusen 1-1 Borussia Dortmund |
| 14 | Sun 10 Dec | 11-1 v VfB StuttgartVfB Stuttgart 1-1 Bayer 04 Leverkusen |
| 15 | Sun 17 Dec | 13-0 v Eintracht FrankfurtBayer 04 Leverkusen 3-0 Eintracht Frankfurt |
| 16 | Wed 20 Dec | 14-0 v VfL BochumBayer 04 Leverkusen 4-0 VfL Bochum |
| 17 | Sat 13 Jan | 11-0 v FC AugsburgFC Augsburg 0-1 Bayer 04 Leverkusen |
| 18 | Sat 20 Jan | 13-2 v RB LeipzigRB Leipzig 2-3 Bayer 04 Leverkusen |
| 19 | Sat 3 Feb | 12-0 v Darmstadt 98Darmstadt 98 0-2 Bayer 04 Leverkusen |
| 20 | Sat 10 Feb | 1 3-0 v Bayern MunichBayer 04 Leverkusen 3-0 Bayern Munich |
| 21 | Sat 17 Feb | 12-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 Bayer 04 Leverkusen |
| 22 | Fri 23 Feb | 12-1 v Mainz 05Bayer 04 Leverkusen 2-1 Mainz 05 |
| 23 | Sun 3 Mar | 12-0 v 1 FC Köln1 FC Köln 0-2 Bayer 04 Leverkusen |
| 24 | Sun 10 Mar | 12-0 v VfL WolfsburgBayer 04 Leverkusen 2-0 VfL Wolfsburg |
| 25 | Sun 17 Mar | 13-2 v SC FreiburgSC Freiburg 2-3 Bayer 04 Leverkusen |
| 26 | Sat 30 Mar | 12-1 v 1899 HoffenheimBayer 04 Leverkusen 2-1 1899 Hoffenheim |
| 27 | Sat 6 Apr | 11-0 v 1 FC Union Berlin1 FC Union Berlin 0-1 Bayer 04 Leverkusen |
| 28 | Sun 14 Apr | 15-0 v Werder BremenBayer 04 Leverkusen 5-0 Werder Bremen |
| 29 | Sun 21 Apr | 11-1 v Borussia DortmundBorussia Dortmund 1-1 Bayer 04 Leverkusen |
| 30 | Sat 27 Apr | 12-2 v VfB StuttgartBayer 04 Leverkusen 2-2 VfB Stuttgart |
| 31 | Sun 5 May | 15-1 v Eintracht FrankfurtEintracht Frankfurt 1-5 Bayer 04 Leverkusen |
| 32 | Sun 12 May | 15-0 v VfL BochumVfL Bochum 0-5 Bayer 04 Leverkusen |
| 33 | Sat 18 May | 12-1 v FC AugsburgBayer 04 Leverkusen 2-1 FC Augsburg |
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