| 1 | Sat 14 Sep | 30-0 v 1 FC Union BerlinRB Leipzig 0-0 1 FC Union Berlin |
| 2 | Sun 22 Sep | 30-0 v FC St PauliFC St Pauli 0-0 RB Leipzig |
| 3 | Sat 28 Sep | 34-0 v FC AugsburgRB Leipzig 4-0 FC Augsburg |
| 4 | Sun 6 Oct | 31-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 RB Leipzig |
| 5 | Sat 19 Oct | 32-0 v Mainz 05Mainz 05 0-2 RB Leipzig |
| 6 | Sat 26 Oct | 3 3-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg |
| 7 | Sat 2 Nov | 3 1-2 v Borussia DortmundBorussia Dortmund 2-1 RB Leipzig |
| 8 | Sat 23 Nov | 33-4 v 1899 Hoffenheim1899 Hoffenheim 4-3 RB Leipzig |
| 9 | Sat 30 Nov | 31-5 v VfL WolfsburgRB Leipzig 1-5 VfL Wolfsburg |
| 10 | Sat 7 Dec | 32-0 v Holstein KielHolstein Kiel 0-2 RB Leipzig |
| 11 | Sun 15 Dec | 32-1 v Eintracht FrankfurtRB Leipzig 2-1 Eintracht Frankfurt |
| 12 | Fri 20 Dec | 31-5 v Bayern MunichBayern Munich 5-1 RB Leipzig |
| 13 | Sun 12 Jan | 34-2 v Werder BremenRB Leipzig 4-2 Werder Bremen |
| 14 | Wed 15 Jan | 31-2 v VfB StuttgartVfB Stuttgart 2-1 RB Leipzig |
| 15 | Sun 9 Feb | 3 2-0 v FC St PauliRB Leipzig 2-0 FC St Pauli |
| 16 | Fri 14 Feb | 30-0 v FC AugsburgFC Augsburg 0-0 RB Leipzig |
| 17 | Sat 1 Mar | 31-2 v Mainz 05RB Leipzig 1-2 Mainz 05 |
| 18 | Sat 8 Mar | 30-0 v SC FreiburgSC Freiburg 0-0 RB Leipzig |
| 19 | Sat 15 Mar | 32-0 v Borussia DortmundRB Leipzig 2-0 Borussia Dortmund |
| 20 | Fri 11 Apr | 33-2 v VfL WolfsburgVfL Wolfsburg 2-3 RB Leipzig |
| 21 | Sat 19 Apr | 31-1 v Holstein KielRB Leipzig 1-1 Holstein Kiel |
| 22 | Sat 26 Apr | 30-4 v Eintracht FrankfurtEintracht Frankfurt 4-0 RB Leipzig |
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