| 1 | Sat 24 Aug | 213-2 v Holstein Kiel1899 Hoffenheim 3-2 Holstein Kiel |
| 2 | Sat 31 Aug | 211-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 1899 Hoffenheim |
| 3 | Sat 14 Sep | 211-4 v Bayer 04 Leverkusen1899 Hoffenheim 1-4 Bayer 04 Leverkusen |
| 4 | Sat 21 Sep | 211-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 1899 Hoffenheim |
| 5 | Sun 29 Sep | 213-4 v Werder Bremen1899 Hoffenheim 3-4 Werder Bremen |
| 6 | Sun 6 Oct | 211-1 v VfB StuttgartVfB Stuttgart 1-1 1899 Hoffenheim |
| 7 | Sat 19 Oct | 21 3-1 v VfL Bochum1899 Hoffenheim 3-1 VfL Bochum |
| 8 | Sun 27 Oct | 210-0 v 1 FC Heidenheim1 FC Heidenheim 0-0 1899 Hoffenheim |
| 9 | Sat 2 Nov | 210-2 v FC St Pauli1899 Hoffenheim 0-2 FC St Pauli |
| 10 | Sun 10 Nov | 21 0-0 v FC AugsburgFC Augsburg 0-0 1899 Hoffenheim |
| 11 | Sat 23 Nov | 214-3 v RB Leipzig1899 Hoffenheim 4-3 RB Leipzig |
| 12 | Sun 26 Jan | 212-2 v Eintracht Frankfurt1899 Hoffenheim 2-2 Eintracht Frankfurt |
| 13 | Sun 2 Feb | 211-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-1 1899 Hoffenheim |
| 14 | Sat 8 Feb | 21 0-4 v 1 FC Union Berlin1899 Hoffenheim 0-4 1 FC Union Berlin |
| 15 | Sun 16 Feb | 213-1 v Werder BremenWerder Bremen 1-3 1899 Hoffenheim |
| 16 | Sun 23 Feb | 211-1 v VfB Stuttgart1899 Hoffenheim 1-1 VfB Stuttgart |
| 17 | Fri 14 Mar | 210-1 v FC St PauliFC St Pauli 1-0 1899 Hoffenheim |
| 18 | Sat 29 Mar | 21 1-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg |
| 19 | Sat 5 Apr | 211-3 v RB LeipzigRB Leipzig 3-1 1899 Hoffenheim |
| 20 | Sat 12 Apr | 212-0 v Mainz 051899 Hoffenheim 2-0 Mainz 05 |
| 21 | Sat 19 Apr | 212-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim |
| 22 | Sat 26 Apr | 212-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund |
| 23 | Sat 3 May | 214-4 v Borussia MönchengladbachBorussia Mönchengladbach 4-4 1899 Hoffenheim |
| 24 | Fri 9 May | 212-2 v VfL WolfsburgVfL Wolfsburg 2-2 1899 Hoffenheim |
| 25 | Sat 17 May | 210-4 v Bayern Munich1899 Hoffenheim 0-4 Bayern Munich |
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