| 1 | Sat 19 Aug | 22-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig |
| 2 | Fri 25 Aug | 25-1 v VfB StuttgartRB Leipzig 5-1 VfB Stuttgart |
| 3 | Sun 3 Sep | 23-0 v 1 FC Union Berlin1 FC Union Berlin 0-3 RB Leipzig |
| 4 | Sat 16 Sep | 23-0 v FC AugsburgRB Leipzig 3-0 FC Augsburg |
| 5 | Sat 23 Sep | 21-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 RB Leipzig |
| 6 | Sat 30 Sep | 2 2-2 v Bayern MunichRB Leipzig 2-2 Bayern Munich |
| 7 | Sat 7 Oct | 20-0 v VfL BochumRB Leipzig 0-0 VfL Bochum |
| 8 | Sat 21 Oct | 23-1 v Darmstadt 98Darmstadt 98 1-3 RB Leipzig |
| 9 | Sat 28 Oct | 2 6-0 v 1 FC KölnRB Leipzig 6-0 1 FC Köln |
| 10 | Sat 4 Nov | 20-2 v Mainz 05Mainz 05 2-0 RB Leipzig |
| 11 | Sun 12 Nov | 23-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg |
| 12 | Sat 25 Nov | 21-2 v VfL WolfsburgVfL Wolfsburg 2-1 RB Leipzig |
| 13 | Sat 2 Dec | 2 2-1 v 1 FC HeidenheimRB Leipzig 2-1 1 FC Heidenheim |
| 14 | Sat 9 Dec | 2 3-2 v Borussia DortmundBorussia Dortmund 2-3 RB Leipzig |
| 15 | Sat 16 Dec | 23-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim |
| 16 | Tue 19 Dec | 21-1 v Werder BremenWerder Bremen 1-1 RB Leipzig |
| 17 | Sat 13 Jan | 20-1 v Eintracht FrankfurtRB Leipzig 0-1 Eintracht Frankfurt |
| 18 | Sat 20 Jan | 22-3 v Bayer 04 LeverkusenRB Leipzig 2-3 Bayer 04 Leverkusen |
| 19 | Sat 27 Jan | 2 2-5 v VfB StuttgartVfB Stuttgart 5-2 RB Leipzig |
| 20 | Sat 10 Feb | 22-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig |
| 21 | Sat 17 Feb | 22-0 v Borussia MönchengladbachRB Leipzig 2-0 Borussia Mönchengladbach |
| 22 | Sat 24 Feb | 2 1-2 v Bayern MunichBayern Munich 2-1 RB Leipzig |
| 23 | Sat 2 Mar | 2 4-1 v VfL BochumVfL Bochum 1-4 RB Leipzig |
| 24 | Sat 9 Mar | 22-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 |
| 25 | Fri 15 Mar | 25-1 v 1 FC Köln1 FC Köln 1-5 RB Leipzig |
| 26 | Sat 30 Mar | 20-0 v Mainz 05RB Leipzig 0-0 Mainz 05 |
| 27 | Sat 6 Apr | 24-1 v SC FreiburgSC Freiburg 1-4 RB Leipzig |
| 28 | Sat 13 Apr | 23-0 v VfL WolfsburgRB Leipzig 3-0 VfL Wolfsburg |
| 29 | Sat 20 Apr | 22-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 RB Leipzig |
| 30 | Sat 27 Apr | 2 4-1 v Borussia DortmundRB Leipzig 4-1 Borussia Dortmund |
| 31 | Fri 3 May | 21-1 v 1899 Hoffenheim1899 Hoffenheim 1-1 RB Leipzig |
| 32 | Sat 11 May | 21-1 v Werder BremenRB Leipzig 1-1 Werder Bremen |
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