| 1 | Mon 16 Aug 2021 | 220-0 v VillarrealVillarreal 0-0 Granada | Spanish La Liga |
| 2 | Sat 21 Aug 2021 | 22 1-1 v ValenciaGranada 1-1 Valencia | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 220-4 v Rayo VallecanoRayo Vallecano 4-0 Granada | Spanish La Liga |
| 4 | Mon 13 Sep 2021 | 221-2 v Real BetisGranada 1-2 Real Betis | Spanish La Liga |
| 5 | Mon 20 Sep 2021 | 221-1 v BarcelonaBarcelona 1-1 Granada | Spanish La Liga |
| 6 | Thu 23 Sep 2021 | 22 2-3 v Real SociedadGranada 2-3 Real Sociedad | Spanish La Liga |
| 7 | Mon 27 Sep 2021 | 22 0-1 v Celta VigoCelta Vigo 1-0 Granada | Spanish La Liga |
| 8 | Sat 8 Jan 2022 | 221-1 v BarcelonaGranada 1-1 Barcelona | Spanish La Liga |
| 9 | Thu 20 Jan 2022 | 222-4 v GetafeGetafe 4-2 Granada | Spanish La Liga |
| 10 | Sun 13 Feb 2022 | 220-2 v Real SociedadReal Sociedad 2-0 Granada | Spanish La Liga |
| 11 | Mon 28 Feb 2022 | 22 0-0 v CádizGranada 0-0 Cádiz | Spanish La Liga |
| 12 | Sat 12 Mar 2022 | 220-1 v ElcheGranada 0-1 Elche | Spanish La Liga |
| 13 | Sat 19 Mar 2022 | 223-2 v AlavésAlavés 2-3 Granada | Spanish La Liga |
| 14 | Sun 3 Apr 2022 | 222-2 v Rayo VallecanoGranada 2-2 Rayo Vallecano | Spanish La Liga |
| 15 | Fri 8 Apr 2022 | 222-4 v SevillaSevilla 4-2 Granada | Spanish La Liga |
| 16 | Sun 17 Apr 2022 | 221-4 v LevanteGranada 1-4 Levante | Spanish La Liga |
| 17 | Wed 20 Apr 2022 | 22 0-0 v Atlético MadridAtlético Madrid 0-0 Granada | Spanish La Liga |
| 18 | Sat 7 May 2022 | 22 6-2 v MallorcaMallorca 2-6 Granada | Spanish La Liga |
| 19 | Tue 10 May 2022 | 22 1-0 v Athletic BilbaoGranada 1-0 Athletic Bilbao | Spanish La Liga |
| 20 | Sun 15 May 2022 | 220-2 v Real BetisReal Betis 2-0 Granada | Spanish La Liga |
| 21 | Sun 22 May 2022 | 220-0 v EspanyolGranada 0-0 Espanyol | Spanish La Liga |
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