| 1 | Sat 5 Sep 2020 | 41-1 v MorecambeGrimsby Town 1-1 Morecambe | Carabao Cup First Round North |
| 2 | Sat 10 Oct 2020 | 40-0 v Bolton WanderersBolton Wanderers 0-0 Grimsby Town | Sky Bet League Two |
| 3 | Sat 17 Oct 2020 | 43-2 v Leyton OrientLeyton Orient 2-3 Grimsby Town | Sky Bet League Two |
| 4 | Sat 31 Oct 2020 | 40-0 v StevenageStevenage 0-0 Grimsby Town | Sky Bet League Two |
| 5 | Tue 3 Nov 2020 | 41-0 v BarrowGrimsby Town 1-0 Barrow | Sky Bet League Two |
| 6 | Tue 17 Nov 2020 | 40-3 v Hull CityHull City 3-0 Grimsby Town | Papa John’s Trophy Group 10 |
| 7 | Sat 21 Nov 2020 | 40-5 v Tranmere RoversTranmere Rovers 5-0 Grimsby Town | Sky Bet League Two |
| 8 | Tue 24 Nov 2020 | 42-1 v Crawley TownCrawley Town 1-2 Grimsby Town | Sky Bet League Two |
| 9 | Tue 1 Dec 2020 | 4 1-4 v Exeter CityGrimsby Town 1-4 Exeter City | Sky Bet League Two |
| 10 | Sat 5 Dec 2020 | 41-2 v Colchester UnitedColchester United 2-1 Grimsby Town | Sky Bet League Two |
| 11 | Tue 8 Dec 2020 | 40-2 v Newport CountyGrimsby Town 0-2 Newport County | Sky Bet League Two |
| 12 | Sat 12 Dec 2020 | 41-1 v Mansfield TownGrimsby Town 1-1 Mansfield Town | Sky Bet League Two |
| 13 | Tue 15 Dec 2020 | 41-3 v Southend UnitedSouthend United 3-1 Grimsby Town | Sky Bet League Two |
| 14 | Tue 22 Dec 2020 | 41-2 v Bradford CityGrimsby Town 1-2 Bradford City | Sky Bet League Two |
| 15 | Tue 29 Dec 2020 | 40-0 v Oldham AthleticGrimsby Town 0-0 Oldham Athletic | Sky Bet League Two |
| 16 | Sat 2 Jan 2021 | 41-2 v Cambridge UnitedGrimsby Town 1-2 Cambridge United | Sky Bet League Two |
| 17 | Sat 9 Jan 2021 | 40-3 v Port ValePort Vale 3-0 Grimsby Town | Sky Bet League Two |
| 18 | Sat 23 Jan 2021 | 40-3 v Scunthorpe UnitedScunthorpe United 3-0 Grimsby Town | Sky Bet League Two |
| 19 | Sat 30 Jan 2021 | 41-2 v StevenageGrimsby Town 1-2 Stevenage | Sky Bet League Two |
| 20 | Tue 23 Feb 2021 | 42-1 v Crawley TownGrimsby Town 2-1 Crawley Town | Sky Bet League Two |
| 21 | Tue 2 Mar 2021 | 40-1 v Leyton OrientGrimsby Town 0-1 Leyton Orient | Sky Bet League Two |
| 22 | Tue 23 Mar 2021 | 41-0 v BarrowBarrow 0-1 Grimsby Town | Sky Bet League Two |
| 23 | Sat 27 Mar 2021 | 41-1 v WalsallGrimsby Town 1-1 Walsall | Sky Bet League Two |
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