| 1 | 5/9/2020 | 11-1 v MorecambeGrimsby Town 1-1 Morecambe | Carabao Cup First Round North |
| 2 | 19/9/2020 | 10-4 v Salford CityGrimsby Town 0-4 Salford City | Sky Bet League Two |
| 3 | 10/10/2020 | 10-0 v Bolton WanderersBolton Wanderers 0-0 Grimsby Town | Sky Bet League Two |
| 4 | 13/10/2020 | 13-1 v Cheltenham TownCheltenham Town 1-3 Grimsby Town | Sky Bet League Two |
| 5 | 17/10/2020 | 13-2 v Leyton OrientLeyton Orient 2-3 Grimsby Town | Sky Bet League Two |
| 6 | 20/10/2020 | 11-2 v Harrogate TownGrimsby Town 1-2 Harrogate Town | Sky Bet League Two |
| 7 | 24/10/2020 | 11-1 v Carlisle UnitedGrimsby Town 1-1 Carlisle United | Sky Bet League Two |
| 8 | 27/10/2020 | 10-1 v Forest Green RoversForest Green Rovers 1-0 Grimsby Town | Sky Bet League Two |
| 9 | 31/10/2020 | 10-0 v StevenageStevenage 0-0 Grimsby Town | Sky Bet League Two |
| 10 | 3/11/2020 | 1 1-0 v BarrowGrimsby Town 1-0 Barrow | Sky Bet League Two |
| 11 | 17/11/2020 | 10-3 v Hull CityHull City 3-0 Grimsby Town | Checkatrade Trophy Group 10 |
| 12 | 21/11/2020 | 10-5 v Tranmere RoversTranmere Rovers 5-0 Grimsby Town | Sky Bet League Two |
| 13 | 24/11/2020 | 12-1 v Crawley TownCrawley Town 1-2 Grimsby Town | Sky Bet League Two |
| 14 | 1/12/2020 | 11-4 v Exeter CityGrimsby Town 1-4 Exeter City | Sky Bet League Two |
| 15 | 5/12/2020 | 11-2 v Colchester UnitedColchester United 2-1 Grimsby Town | Sky Bet League Two |
| 16 | 8/12/2020 | 10-2 v Newport CountyGrimsby Town 0-2 Newport County | Sky Bet League Two |
| 17 | 12/12/2020 | 11-1 v Mansfield TownGrimsby Town 1-1 Mansfield Town | Sky Bet League Two |
| 18 | 15/12/2020 | 11-3 v Southend UnitedSouthend United 3-1 Grimsby Town | Sky Bet League Two |
| 19 | 19/12/2020 | 11-0 v Scunthorpe UnitedGrimsby Town 1-0 Scunthorpe United | Sky Bet League Two |
| 20 | 22/12/2020 | 11-2 v Bradford CityGrimsby Town 1-2 Bradford City | Sky Bet League Two |
| 21 | 26/12/2020 | 11-3 v MorecambeMorecambe 3-1 Grimsby Town | Sky Bet League Two |
| 22 | 9/1/2021 | 10-3 v Port ValePort Vale 3-0 Grimsby Town | Sky Bet League Two |
| 23 | 16/1/2021 | 10-0 v Southend UnitedGrimsby Town 0-0 Southend United | Sky Bet League Two |
| 24 | 23/1/2021 | 10-3 v Scunthorpe UnitedScunthorpe United 3-0 Grimsby Town | Sky Bet League Two |
| 25 | 30/1/2021 | 1 1-2 v StevenageGrimsby Town 1-2 Stevenage | Sky Bet League Two |
| 26 | 6/2/2021 | 10-1 v Newport CountyNewport County 1-0 Grimsby Town | Sky Bet League Two |
| 27 | 23/2/2021 | 12-1 v Crawley TownGrimsby Town 2-1 Crawley Town | Sky Bet League Two |
| 28 | 27/2/2021 | 10-1 v Harrogate TownHarrogate Town 1-0 Grimsby Town | Sky Bet League Two |
| 29 | 2/3/2021 | 10-1 v Leyton OrientGrimsby Town 0-1 Leyton Orient | Sky Bet League Two |
| 30 | 6/3/2021 | 11-2 v Forest Green RoversGrimsby Town 1-2 Forest Green Rovers | Sky Bet League Two |
| 31 | 9/3/2021 | 11-1 v Carlisle UnitedCarlisle United 1-1 Grimsby Town | Sky Bet League Two |
| 32 | 13/3/2021 | 10-0 v Colchester UnitedGrimsby Town 0-0 Colchester United | Sky Bet League Two |
| 33 | 17/3/2021 | 10-0 v Tranmere RoversGrimsby Town 0-0 Tranmere Rovers | Sky Bet League Two |
| 34 | 20/3/2021 | 12-2 v Mansfield TownMansfield Town 2-2 Grimsby Town | Sky Bet League Two |
| 35 | 23/3/2021 | 11-0 v BarrowBarrow 0-1 Grimsby Town | Sky Bet League Two |
| 36 | 27/3/2021 | 11-1 v WalsallGrimsby Town 1-1 Walsall | Sky Bet League Two |
| 37 | 2/4/2021 | 11-1 v Salford CitySalford City 1-1 Grimsby Town | Sky Bet League Two |
| 38 | 5/4/2021 | 11-1 v Cheltenham TownGrimsby Town 1-1 Cheltenham Town | Sky Bet League Two |
| 39 | 10/4/2021 | 10-1 v Bradford CityBradford City 1-0 Grimsby Town | Sky Bet League Two |
| 40 | 17/4/2021 | 12-1 v Bolton WanderersGrimsby Town 2-1 Bolton Wanderers | Sky Bet League Two |
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