| 1 | Sat 6 Jul | 220-7 v Huddersfield TownGuiseley 0-7 Huddersfield Town | Friendly |
| 2 | Sat 13 Jul | 112-1 v Bradford CityGuiseley 2-1 Bradford City | Friendly |
| 3 | Sat 27 Jul | 71-0 v Leeds UnitedGuiseley 1-0 Leeds United | Friendly |
| 4 | Tue 30 Jul | 20-4 v BarnsleyGuiseley 0-4 Barnsley | Friendly |
| 5 | Sat 10 Aug | 72-0 v Workington AFCGuiseley 2-0 Workington AFC | Northern Premier League - Premier Division |
| 6 | Wed 14 Aug | 71-3 v Stockton TownStockton Town 3-1 Guiseley | Northern Premier League - Premier Division |
| 7 | Sat 17 Aug | 71-3 v MacclesfieldMacclesfield 3-1 Guiseley | Northern Premier League - Premier Division |
| 8 | Tue 20 Aug | 70-0 v Blyth SpartansGuiseley 0-0 Blyth Spartans | Northern Premier League - Premier Division |
| 9 | Sat 24 Aug | 73-2 v FC United of ManchesterGuiseley 3-2 FC United of Manchester | Northern Premier League - Premier Division |
| 10 | Mon 26 Aug | 73-2 v Bamber BridgeBamber Bridge 2-3 Guiseley | Northern Premier League - Premier Division |
| 11 | Sat 31 Aug | 73-0 v Ashton UnitedGuiseley 3-0 Ashton United | Emirates FA Cup First Qualifying Round |
| 12 | Sat 7 Sep | 74-0 v Hyde UnitedGuiseley 4-0 Hyde United | Northern Premier League - Premier Division |
| 13 | Tue 10 Sep | 72-1 v Whitby TownWhitby Town 1-2 Guiseley | Northern Premier League - Premier Division |
| 14 | Sat 14 Sep | 73-0 v 1874 NorthwichGuiseley 3-0 1874 Northwich | Emirates FA Cup Second Qualifying Round |
| 15 | Tue 17 Sep | 123-3 v Morpeth TownGuiseley 3-3 Morpeth Town | Northern Premier League - Premier Division |
| 16 | Sat 21 Sep | 141-2 v Worksop TownGuiseley 1-2 Worksop Town | Northern Premier League - Premier Division |
| 17 | Sat 28 Sep | 71-0 v Scunthorpe UnitedGuiseley 1-0 Scunthorpe United | Emirates FA Cup Third Qualifying Round |
| 18 | Tue 1 Oct | 72-0 v Basford UnitedBasford United 0-2 Guiseley | Northern Premier League - Premier Division |
| 19 | Sat 5 Oct | 70-1 v Bamber BridgeGuiseley 0-1 Bamber Bridge | Isuzu FA Trophy Third Qualifying Round |
| 20 | Sat 12 Oct | 71-0 v Kidderminster HarriersKidderminster Harriers 0-1 Guiseley | Emirates FA Cup Fourth Qualifying Round |
| 21 | Tue 15 Oct | 71-1 v Lancaster CityLancaster City 1-1 Guiseley | Northern Premier League - Premier Division |
| 22 | Sat 19 Oct | 71-1 v Ilkeston TownIlkeston Town 1-1 Guiseley | Northern Premier League - Premier Division |
| 23 | Sat 2 Nov | 7 1-1 v StevenageStevenage 1-1 Guiseley | Emirates FA Cup First Round |
| 24 | Sat 9 Nov | 71-0 v MickleoverMickleover 0-1 Guiseley | Northern Premier League - Premier Division |
| 25 | Tue 12 Nov | 72-0 v Prescot CablesGuiseley 2-0 Prescot Cables | Northern Premier League - Premier Division |
| 26 | Sat 16 Nov | 72-0 v Hebburn TownGuiseley 2-0 Hebburn Town | Northern Premier League - Premier Division |
| 27 | Tue 19 Nov | 74-2 v Ashton UnitedAshton United 2-4 Guiseley | Northern Premier League - Premier Division |
| 28 | Sat 30 Nov | 72-2 v Warrington RylandsGuiseley 2-2 Warrington Rylands | Northern Premier League - Premier Division |
| 29 | Sat 7 Dec | 73-1 v Whitby TownGuiseley 3-1 Whitby Town | Northern Premier League - Premier Division |
| 30 | Tue 10 Dec | 71-1 v Leek TownGuiseley 1-1 Leek Town | Northern Premier League - Premier Division |
| 31 | Sat 14 Dec | 71-1 v Hyde UnitedHyde United 1-1 Guiseley | Northern Premier League - Premier Division |
| 32 | Sat 21 Dec | 171-1 v Stockton TownGuiseley 1-1 Stockton Town | Northern Premier League - Premier Division |
| 33 | Wed 1 Jan | 163-1 v Bamber BridgeGuiseley 3-1 Bamber Bridge | Northern Premier League - Premier Division |
| 34 | Sat 4 Jan | 92-0 v Workington AFCWorkington AFC 0-2 Guiseley | Northern Premier League - Premier Division |
| 35 | Sat 25 Jan | 74-1 v Worksop TownWorksop Town 1-4 Guiseley | Northern Premier League - Premier Division |
| 36 | Tue 28 Jan | 70-2 v Morpeth TownMorpeth Town 2-0 Guiseley | Northern Premier League - Premier Division |
| 37 | Sat 1 Feb | 71-2 v Lancaster CityGuiseley 1-2 Lancaster City | Northern Premier League - Premier Division |
| 38 | Sat 8 Feb | 170-2 v Prescot CablesPrescot Cables 2-0 Guiseley | Northern Premier League - Premier Division |
| 39 | Sat 22 Feb | 92-2 v Leek TownLeek Town 2-2 Guiseley | Northern Premier League - Premier Division |
| 40 | Sat 1 Mar | 71-0 v Ashton UnitedGuiseley 1-0 Ashton United | Northern Premier League - Premier Division |
| 41 | Sat 15 Mar | 173-0 v MickleoverGuiseley 3-0 Mickleover | Northern Premier League - Premier Division |
| 42 | Sat 22 Mar | 91-0 v Hebburn TownHebburn Town 0-1 Guiseley | Northern Premier League - Premier Division |
| 43 | Sat 29 Mar | 71-1 v Matlock TownGuiseley 1-1 Matlock Town | Northern Premier League - Premier Division |
| 44 | Sat 5 Apr | 91-1 v Warrington RylandsWarrington Rylands 1-1 Guiseley | Northern Premier League - Premier Division |
| 45 | Sat 12 Apr | 7 0-3 v MacclesfieldGuiseley 0-3 Macclesfield | Northern Premier League - Premier Division |
| 46 | Sat 19 Apr | 72-0 v Blyth SpartansBlyth Spartans 0-2 Guiseley | Northern Premier League - Premier Division |
| 47 | Mon 21 Apr | 70-2 v Gainsborough TrinityGuiseley 0-2 Gainsborough Trinity | Northern Premier League - Premier Division |
| 48 | Sat 26 Apr | 71-1 v FC United of ManchesterFC United of Manchester 1-1 Guiseley | Northern Premier League - Premier Division |
| 49 | Tue 29 Apr | 7 0-1 v Stockton TownStockton Town 1-0 Guiseley | Northern Premier League - Premier Division Play-off Semi Final |
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