| 1 | Sat 23 Jan 2021 | 251-0 v sc HeerenveenHeracles Almelo 1-0 sc Heerenveen | Dutch Eredivisie |
| 2 | Tue 26 Jan 2021 | 252-2 v PEC ZwollePEC Zwolle 2-2 Heracles Almelo | Dutch Eredivisie |
| 3 | Sat 30 Jan 2021 | 251-0 v FC GroningenHeracles Almelo 1-0 FC Groningen | Dutch Eredivisie |
| 4 | Fri 5 Feb 2021 | 25 1-0 v Fortuna SittardFortuna Sittard 0-1 Heracles Almelo | Dutch Eredivisie |
| 5 | Sat 13 Feb 2021 | 250-2 v AjaxHeracles Almelo 0-2 Ajax | Dutch Eredivisie |
| 6 | Sun 21 Feb 2021 | 250-3 v RKC WaalwijkRKC Waalwijk 3-0 Heracles Almelo | Dutch Eredivisie |
| 7 | Sat 27 Feb 2021 | 252-2 v FC TwenteHeracles Almelo 2-2 FC Twente | Dutch Eredivisie |
| 8 | Sun 7 Mar 2021 | 252-1 v PEC ZwolleHeracles Almelo 2-1 PEC Zwolle | Dutch Eredivisie |
| 9 | Sat 13 Mar 2021 | 252-1 v ADO Den HaagADO Den Haag 1-2 Heracles Almelo | Dutch Eredivisie |
| 10 | Sun 21 Mar 2021 | 251-1 v Sparta RotterdamHeracles Almelo 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 11 | Sat 10 Apr 2021 | 254-0 v Willem IIHeracles Almelo 4-0 Willem II | Dutch Eredivisie |
| 12 | Sun 25 Apr 2021 | 251-3 v FC EmmenFC Emmen 3-1 Heracles Almelo | Dutch Eredivisie |
| 13 | Sat 1 May 2021 | 254-0 v VVV VenloHeracles Almelo 4-0 VVV Venlo | Dutch Eredivisie |
| 14 | Sat 8 May 2021 | 251-1 v FC TwenteFC Twente 1-1 Heracles Almelo | Dutch Eredivisie |
| 15 | Thu 13 May 2021 | 251-1 v FeyenoordHeracles Almelo 1-1 Feyenoord | Dutch Eredivisie |
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