| 1 | Sat 14 Aug 2021 | 30-3 v Queens Park RangersHull City 0-3 Queens Park Rangers | Sky Bet Championship |
| 2 | Wed 18 Aug 2021 | 30-1 v Derby CountyHull City 0-1 Derby County | Sky Bet Championship |
| 3 | Sat 21 Aug 2021 | 30-2 v FulhamFulham 2-0 Hull City | Sky Bet Championship |
| 4 | Sat 28 Aug 2021 | 30-0 v AFC BournemouthHull City 0-0 AFC Bournemouth | Sky Bet Championship |
| 5 | Sat 11 Sep 2021 | 30-0 v Swansea CitySwansea City 0-0 Hull City | Sky Bet Championship |
| 6 | Tue 14 Sep 2021 | 3 0-2 v Blackburn RoversBlackburn Rovers 2-0 Hull City | Sky Bet Championship |
| 7 | Sat 18 Sep 2021 | 31-3 v Sheffield UnitedHull City 1-3 Sheffield United | Sky Bet Championship |
| 8 | Sat 25 Sep 2021 | 30-2 v Stoke CityStoke City 2-0 Hull City | Sky Bet Championship |
| 9 | Tue 28 Sep 2021 | 31-1 v BlackpoolHull City 1-1 Blackpool | Sky Bet Championship |
| 10 | Sat 16 Oct 2021 | 30-2 v Huddersfield TownHuddersfield Town 2-0 Hull City | Sky Bet Championship |
| 11 | Wed 20 Oct 2021 | 31-2 v Peterborough UnitedHull City 1-2 Peterborough United | Sky Bet Championship |
| 12 | Sat 23 Oct 2021 | 30-1 v Luton TownLuton Town 1-0 Hull City | Sky Bet Championship |
| 13 | Sat 30 Oct 2021 | 30-1 v Coventry CityHull City 0-1 Coventry City | Sky Bet Championship |
| 14 | Wed 3 Nov 2021 | 30-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Hull City | Sky Bet Championship |
| 15 | Sat 6 Nov 2021 | 32-0 v BarnsleyBarnsley 0-2 Hull City | Sky Bet Championship |
| 16 | Wed 24 Nov 2021 | 31-0 v Cardiff CityCardiff City 0-1 Hull City | Sky Bet Championship |
| 17 | Sat 27 Nov 2021 | 32-1 v MillwallHull City 2-1 Millwall | Sky Bet Championship |
| 18 | Sat 4 Dec 2021 | 3 1-1 v ReadingReading 1-1 Hull City | Sky Bet Championship |
| 19 | Sat 18 Dec 2021 | 31-2 v Nottingham ForestNottingham Forest 2-1 Hull City | Sky Bet Championship |
| 20 | Sat 1 Jan 2022 | 30-1 v BlackpoolBlackpool 1-0 Hull City | Sky Bet Championship |
| 21 | Tue 15 Feb 2022 | 30-0 v Sheffield UnitedSheffield United 0-0 Hull City | Sky Bet Championship |
| 22 | Sat 19 Feb 2022 | 31-1 v Queens Park RangersQueens Park Rangers 1-1 Hull City | Sky Bet Championship |
| 23 | Wed 16 Mar 2022 | 32-0 v Coventry CityCoventry City 0-2 Hull City | Sky Bet Championship |
| 24 | Sat 19 Mar 2022 | 31-3 v Luton TownHull City 1-3 Luton Town | Sky Bet Championship |
| 25 | Fri 1 Apr 2022 | 30-1 v Huddersfield TownHull City 0-1 Huddersfield Town | Sky Bet Championship |
| 26 | Sat 9 Apr 2022 | 31-0 v MiddlesbroughMiddlesbrough 0-1 Hull City | Sky Bet Championship |
| 27 | Mon 18 Apr 2022 | 31-2 v MillwallMillwall 2-1 Hull City | Sky Bet Championship |
| 28 | Sat 7 May 2022 | 31-1 v Nottingham ForestHull City 1-1 Nottingham Forest | Sky Bet Championship |
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