| 1 | 7/8/2021 | 84-1 v Preston North EndPreston North End 1-4 Hull City | Sky Bet Championship |
| 2 | 14/8/2021 | 80-3 v Queens Park RangersHull City 0-3 Queens Park Rangers | Sky Bet Championship |
| 3 | 18/8/2021 | 80-1 v Derby CountyHull City 0-1 Derby County | Sky Bet Championship |
| 4 | 21/8/2021 | 80-2 v FulhamFulham 2-0 Hull City | Sky Bet Championship |
| 5 | 28/8/2021 | 80-0 v AFC BournemouthHull City 0-0 AFC Bournemouth | Sky Bet Championship |
| 6 | 11/9/2021 | 80-0 v Swansea CitySwansea City 0-0 Hull City | Sky Bet Championship |
| 7 | 14/9/2021 | 80-2 v Blackburn RoversBlackburn Rovers 2-0 Hull City | Sky Bet Championship |
| 8 | 25/9/2021 | 80-2 v Stoke CityStoke City 2-0 Hull City | Sky Bet Championship |
| 9 | 28/9/2021 | 81-1 v BlackpoolHull City 1-1 Blackpool | Sky Bet Championship |
| 10 | 2/10/2021 | 82-0 v MiddlesbroughHull City 2-0 Middlesbrough | Sky Bet Championship |
| 11 | 16/10/2021 | 80-2 v Huddersfield TownHuddersfield Town 2-0 Hull City | Sky Bet Championship |
| 12 | 20/10/2021 | 81-2 v Peterborough UnitedHull City 1-2 Peterborough United | Sky Bet Championship |
| 13 | 23/10/2021 | 80-1 v Luton TownLuton Town 1-0 Hull City | Sky Bet Championship |
| 14 | 30/10/2021 | 80-1 v Coventry CityHull City 0-1 Coventry City | Sky Bet Championship |
| 15 | 3/11/2021 | 8 0-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Hull City | Sky Bet Championship |
| 16 | 6/11/2021 | 82-0 v BarnsleyBarnsley 0-2 Hull City | Sky Bet Championship |
| 17 | 20/11/2021 | 8 2-0 v Birmingham CityHull City 2-0 Birmingham City | Sky Bet Championship |
| 18 | 24/11/2021 | 81-0 v Cardiff CityCardiff City 0-1 Hull City | Sky Bet Championship |
| 19 | 27/11/2021 | 82-1 v MillwallHull City 2-1 Millwall | Sky Bet Championship |
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