| 1 | Sun 20 Aug | 302-1 v LazioLecce 2-1 Lazio |
| 2 | Sun 27 Aug | 302-2 v FiorentinaFiorentina 2-2 Lecce |
| 3 | Sun 3 Sep | 302-0 v SalernitanaLecce 2-0 Salernitana |
| 4 | Sun 17 Sep | 301-1 v MonzaMonza 1-1 Lecce |
| 5 | Fri 22 Sep | 301-0 v GenoaLecce 1-0 Genoa |
| 6 | Tue 26 Sep | 300-1 v JuventusJuventus 1-0 Lecce |
| 7 | Sat 30 Sep | 300-4 v NapoliLecce 0-4 Napoli |
| 8 | Fri 6 Oct | 301-1 v SassuoloLecce 1-1 Sassuolo |
| 9 | Mon 23 Oct | 301-1 v UdineseUdinese 1-1 Lecce |
| 10 | Sat 28 Oct | 300-1 v TorinoLecce 0-1 Torino |
| 11 | Sun 5 Nov | 301-2 v RomaRoma 2-1 Lecce |
| 12 | Sat 11 Nov | 302-2 v AC MilanLecce 2-2 AC Milan |
| 13 | Mon 27 Nov | 302-2 v Hellas VeronaHellas Verona 2-2 Lecce |
| 14 | Sun 3 Dec | 301-1 v BolognaLecce 1-1 Bologna |
| 15 | Mon 11 Dec | 301-1 v EmpoliEmpoli 1-1 Lecce |
| 16 | Sat 16 Dec | 302-1 v FrosinoneLecce 2-1 Frosinone |
| 17 | Sat 23 Dec | 300-2 v Inter MilanInter Milan 2-0 Lecce |
| 18 | Sat 30 Dec | 300-1 v AtalantaAtalanta 1-0 Lecce |
| 19 | Sat 6 Jan | 301-1 v CagliariLecce 1-1 Cagliari |
| 20 | Sun 14 Jan | 300-1 v LazioLazio 1-0 Lecce |
| 21 | Sun 21 Jan | 300-3 v JuventusLecce 0-3 Juventus |
| 22 | Sun 28 Jan | 301-2 v GenoaGenoa 2-1 Lecce |
| 23 | Fri 2 Feb | 303-2 v FiorentinaLecce 3-2 Fiorentina |
| 24 | Sun 11 Feb | 300-4 v BolognaBologna 4-0 Lecce |
| 25 | Fri 16 Feb | 300-2 v TorinoTorino 2-0 Lecce |
| 26 | Sun 25 Feb | 300-4 v Inter MilanLecce 0-4 Inter Milan |
| 27 | Sun 3 Mar | 301-1 v FrosinoneFrosinone 1-1 Lecce |
| 28 | Sun 10 Mar | 300-1 v Hellas VeronaLecce 0-1 Hellas Verona |
| 29 | Sat 16 Mar | 301-0 v SalernitanaSalernitana 0-1 Lecce |
| 30 | Mon 1 Apr | 300-0 v RomaLecce 0-0 Roma |
| 31 | Sat 6 Apr | 300-3 v AC MilanAC Milan 3-0 Lecce |
| 32 | Sat 13 Apr | 301-0 v EmpoliLecce 1-0 Empoli |
| 33 | Sun 21 Apr | 303-0 v SassuoloSassuolo 0-3 Lecce |
| 34 | Sat 27 Apr | 301-1 v MonzaLecce 1-1 Monza |
| 35 | Sun 5 May | 301-1 v CagliariCagliari 1-1 Lecce |
| 36 | Mon 13 May | 300-2 v UdineseLecce 0-2 Udinese |
| 37 | Sat 18 May | 300-2 v AtalantaLecce 0-2 Atalanta |
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