| 1 | Sat 19 Sep 2020 | 61-0 v TorinoFiorentina 1-0 Torino |
| 2 | Sat 26 Sep 2020 | 63-4 v Inter MilanInter Milan 4-3 Fiorentina |
| 3 | Sun 22 Nov 2020 | 60-1 v BeneventoFiorentina 0-1 Benevento |
| 4 | Sun 29 Nov 2020 | 60-2 v AC MilanAC Milan 2-0 Fiorentina |
| 5 | Mon 7 Dec 2020 | 6 1-1 v GenoaFiorentina 1-1 Genoa |
| 6 | Wed 16 Dec 2020 | 61-1 v SassuoloFiorentina 1-1 Sassuolo |
| 7 | Sat 19 Dec 2020 | 61-1 v Hellas VeronaFiorentina 1-1 Hellas Verona |
| 8 | Tue 22 Dec 2020 | 6 3-0 v JuventusJuventus 0-3 Fiorentina |
| 9 | Sun 3 Jan 2021 | 60-0 v BolognaFiorentina 0-0 Bologna |
| 10 | Sun 10 Jan 2021 | 61-0 v CagliariFiorentina 1-0 Cagliari |
| 11 | Sun 17 Jan 2021 | 60-6 v NapoliNapoli 6-0 Fiorentina |
| 12 | Sat 23 Jan 2021 | 62-1 v CrotoneFiorentina 2-1 Crotone |
| 13 | Fri 5 Feb 2021 | 60-2 v Inter MilanFiorentina 0-2 Inter Milan |
| 14 | Fri 19 Feb 2021 | 6 3-0 v SpeziaFiorentina 3-0 Spezia |
| 15 | Sun 28 Feb 2021 | 60-1 v UdineseUdinese 1-0 Fiorentina |
| 16 | Wed 3 Mar 2021 | 61-2 v RomaFiorentina 1-2 Roma |
| 17 | Sun 7 Mar 2021 | 63-3 v ParmaFiorentina 3-3 Parma |
| 18 | Sat 13 Mar 2021 | 64-1 v BeneventoBenevento 1-4 Fiorentina |
| 19 | Sun 11 Apr 2021 | 62-3 v AtalantaFiorentina 2-3 Atalanta |
| 20 | Sat 22 May 2021 | 60-0 v CrotoneCrotone 0-0 Fiorentina |
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