| 1 | Sun 18 Oct 2020 | 772-2 v SpeziaSpezia 2-2 Fiorentina |
| 2 | Sun 25 Oct 2020 | 773-2 v UdineseFiorentina 3-2 Udinese |
| 3 | Sun 1 Nov 2020 | 770-2 v RomaRoma 2-0 Fiorentina |
| 4 | Sun 29 Nov 2020 | 770-2 v AC MilanAC Milan 2-0 Fiorentina |
| 5 | Mon 7 Dec 2020 | 771-1 v GenoaFiorentina 1-1 Genoa |
| 6 | Sun 13 Dec 2020 | 770-3 v AtalantaAtalanta 3-0 Fiorentina |
| 7 | Sat 19 Dec 2020 | 771-1 v Hellas VeronaFiorentina 1-1 Hellas Verona |
| 8 | Wed 6 Jan 2021 | 771-2 v LazioLazio 2-1 Fiorentina |
| 9 | Sun 10 Jan 2021 | 771-0 v CagliariFiorentina 1-0 Cagliari |
| 10 | Sun 17 Jan 2021 | 770-6 v NapoliNapoli 6-0 Fiorentina |
| 11 | Sun 14 Feb 2021 | 771-2 v SampdoriaSampdoria 2-1 Fiorentina |
| 12 | Sun 7 Mar 2021 | 773-3 v ParmaFiorentina 3-3 Parma |
| 13 | Sat 13 Mar 2021 | 774-1 v BeneventoBenevento 1-4 Fiorentina |
| 14 | Sun 21 Mar 2021 | 772-3 v AC MilanFiorentina 2-3 AC Milan |
| 15 | Sat 3 Apr 2021 | 771-1 v GenoaGenoa 1-1 Fiorentina |
| 16 | Sun 11 Apr 2021 | 772-3 v AtalantaFiorentina 2-3 Atalanta |
| 17 | Sat 17 Apr 2021 | 771-3 v SassuoloSassuolo 3-1 Fiorentina |
| 18 | Wed 12 May 2021 | 770-0 v CagliariCagliari 0-0 Fiorentina |
| 19 | Sun 16 May 2021 | 770-2 v NapoliFiorentina 0-2 Napoli |
| 20 | Sat 22 May 2021 | 770-0 v CrotoneCrotone 0-0 Fiorentina |
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