| 1 | Sun 27 Sep 2020 | 30-1 v Hellas VeronaHellas Verona 1-0 Udinese |
| 2 | Wed 30 Sep 2020 | 30-2 v SpeziaUdinese 0-2 Spezia |
| 3 | Sat 3 Oct 2020 | 3 0-1 v RomaUdinese 0-1 Roma |
| 4 | Sun 18 Oct 2020 | 33-2 v ParmaUdinese 3-2 Parma |
| 5 | Sun 25 Oct 2020 | 32-3 v FiorentinaFiorentina 3-2 Udinese |
| 6 | Sun 1 Nov 2020 | 31-2 v AC MilanUdinese 1-2 AC Milan |
| 7 | Fri 6 Nov 2020 | 30-0 v SassuoloSassuolo 0-0 Udinese |
| 8 | Sun 22 Nov 2020 | 31-0 v GenoaUdinese 1-0 Genoa |
| 9 | Sun 29 Nov 2020 | 3 3-1 v LazioLazio 1-3 Udinese |
| 10 | Sat 12 Dec 2020 | 33-2 v TorinoTorino 2-3 Udinese |
| 11 | Tue 15 Dec 2020 | 3 0-0 v CrotoneUdinese 0-0 Crotone |
| 12 | Sun 20 Dec 2020 | 31-1 v CagliariCagliari 1-1 Udinese |
| 13 | Wed 23 Dec 2020 | 30-2 v BeneventoUdinese 0-2 Benevento |
| 14 | Sun 3 Jan 2021 | 31-4 v JuventusJuventus 4-1 Udinese |
| 15 | Wed 6 Jan 2021 | 3 2-2 v BolognaBologna 2-2 Udinese |
| 16 | Sun 10 Jan 2021 | 3 1-2 v NapoliUdinese 1-2 Napoli |
| 17 | Sat 16 Jan 2021 | 31-2 v SampdoriaSampdoria 2-1 Udinese |
| 18 | Wed 20 Jan 2021 | 31-1 v AtalantaUdinese 1-1 Atalanta |
| 19 | Sat 23 Jan 2021 | 3 0-0 v Inter MilanUdinese 0-0 Inter Milan |
| 20 | Sun 7 Feb 2021 | 32-0 v Hellas VeronaUdinese 2-0 Hellas Verona |
| 21 | Sun 14 Feb 2021 | 30-3 v RomaRoma 3-0 Udinese |
| 22 | Sun 21 Feb 2021 | 32-2 v ParmaParma 2-2 Udinese |
| 23 | Wed 3 Mar 2021 | 31-1 v AC MilanAC Milan 1-1 Udinese |
| 24 | Sat 3 Apr 2021 | 3 2-3 v AtalantaAtalanta 3-2 Udinese |
| 25 | Sat 10 Apr 2021 | 30-1 v TorinoUdinese 0-1 Torino |
| 26 | Sat 17 Apr 2021 | 32-1 v CrotoneCrotone 1-2 Udinese |
| 27 | Sun 25 Apr 2021 | 34-2 v BeneventoBenevento 2-4 Udinese |
| 28 | Sun 2 May 2021 | 31-2 v JuventusUdinese 1-2 Juventus |
| 29 | Tue 11 May 2021 | 31-5 v NapoliNapoli 5-1 Udinese |
| 30 | Sun 16 May 2021 | 30-1 v SampdoriaUdinese 0-1 Sampdoria |
| 31 | Sun 23 May 2021 | 31-5 v Inter MilanInter Milan 5-1 Udinese |
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