| 1 | Sun 20 Aug | 252-1 v LazioLecce 2-1 Lazio |
| 2 | Sun 27 Aug | 252-2 v FiorentinaFiorentina 2-2 Lecce |
| 3 | Sun 3 Sep | 252-0 v SalernitanaLecce 2-0 Salernitana |
| 4 | Sun 17 Sep | 251-1 v MonzaMonza 1-1 Lecce |
| 5 | Fri 22 Sep | 251-0 v GenoaLecce 1-0 Genoa |
| 6 | Sat 30 Sep | 25 0-4 v NapoliLecce 0-4 Napoli |
| 7 | Fri 6 Oct | 251-1 v SassuoloLecce 1-1 Sassuolo |
| 8 | Mon 23 Oct | 251-1 v UdineseUdinese 1-1 Lecce |
| 9 | Sat 28 Oct | 25 0-1 v TorinoLecce 0-1 Torino |
| 10 | Sun 5 Nov | 251-2 v RomaRoma 2-1 Lecce |
| 11 | Mon 27 Nov | 252-2 v Hellas VeronaHellas Verona 2-2 Lecce |
| 12 | Mon 11 Dec | 251-1 v EmpoliEmpoli 1-1 Lecce |
| 13 | Sat 16 Dec | 252-1 v FrosinoneLecce 2-1 Frosinone |
| 14 | Sat 23 Dec | 250-2 v Inter MilanInter Milan 2-0 Lecce |
| 15 | Sat 30 Dec | 250-1 v AtalantaAtalanta 1-0 Lecce |
| 16 | Sat 6 Jan | 251-1 v CagliariLecce 1-1 Cagliari |
| 17 | Sun 14 Jan | 250-1 v LazioLazio 1-0 Lecce |
| 18 | Sun 21 Jan | 250-3 v JuventusLecce 0-3 Juventus |
| 19 | Sun 28 Jan | 251-2 v GenoaGenoa 2-1 Lecce |
| 20 | Fri 2 Feb | 253-2 v FiorentinaLecce 3-2 Fiorentina |
| 21 | Sun 11 Feb | 250-4 v BolognaBologna 4-0 Lecce |
| 22 | Fri 16 Feb | 250-2 v TorinoTorino 2-0 Lecce |
| 23 | Sun 25 Feb | 250-4 v Inter MilanLecce 0-4 Inter Milan |
| 24 | Sun 3 Mar | 251-1 v FrosinoneFrosinone 1-1 Lecce |
| 25 | Sun 10 Mar | 250-1 v Hellas VeronaLecce 0-1 Hellas Verona |
| 26 | Sat 16 Mar | 251-0 v SalernitanaSalernitana 0-1 Lecce |
| 27 | Mon 1 Apr | 250-0 v RomaLecce 0-0 Roma |
| 28 | Sat 6 Apr | 250-3 v AC MilanAC Milan 3-0 Lecce |
| 29 | Sat 13 Apr | 251-0 v EmpoliLecce 1-0 Empoli |
| 30 | Sun 21 Apr | 253-0 v SassuoloSassuolo 0-3 Lecce |
| 31 | Sat 27 Apr | 251-1 v MonzaLecce 1-1 Monza |
| 32 | Sun 5 May | 251-1 v CagliariCagliari 1-1 Lecce |
| 33 | Mon 13 May | 250-2 v UdineseLecce 0-2 Udinese |
| 34 | Sat 18 May | 250-2 v AtalantaLecce 0-2 Atalanta |
| 35 | Sun 26 May | 250-0 v NapoliNapoli 0-0 Lecce |
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