| 1 | 1/8/2021 | 12-2 v Germinal BeerschotKAA Gent 2-2 Germinal Beerschot | Belgian First Division A |
| 2 | 8/8/2021 | 10-1 v KV OostendeKV Oostende 1-0 KAA Gent | Belgian First Division A |
| 3 | 15/8/2021 | 12-0 v MechelenKAA Gent 2-0 Mechelen | Belgian First Division A |
| 4 | 29/8/2021 | 16-1 v Club BruggeKAA Gent 6-1 Club Brugge | Belgian First Division A |
| 5 | 12/9/2021 | 12-3 v Sporting de CharleroiKAA Gent 2-3 Sporting de Charleroi | Belgian First Division A |
| 6 | 16/9/2021 | 11-0 v FC Flora TallinnFC Flora Tallinn 0-1 KAA Gent | UEFA Europa Conference League |
| 7 | 19/9/2021 | 1 0-1 v KV KortrijkKV Kortrijk 1-0 KAA Gent | Belgian First Division A |
| 8 | 23/9/2021 | 11-1 v RSC AnderlechtRSC Anderlecht 1-1 KAA Gent | Belgian First Division A |
| 9 | 26/9/2021 | 12-1 v Cercle BruggeKAA Gent 2-1 Cercle Brugge | Belgian First Division A |
| 10 | 30/9/2021 | 12-0 v Anorthosis FamagustaKAA Gent 2-0 Anorthosis Famagusta | UEFA Europa Conference League |
| 11 | 3/10/2021 | 10-1 v Royal AntwerpRoyal Antwerp 1-0 KAA Gent | Belgian First Division A |
| 12 | 17/10/2021 | 12-0 v KAS EupenKAA Gent 2-0 KAS Eupen | Belgian First Division A |
| 13 | 21/10/2021 | 11-0 v FK PartizanFK Partizan 0-1 KAA Gent | UEFA Europa Conference League |
| 14 | 24/10/2021 | 13-0 v KRC GenkKRC Genk 0-3 KAA Gent | Belgian First Division A |
| 15 | 4/11/2021 | 11-1 v FK PartizanKAA Gent 1-1 FK Partizan | UEFA Europa Conference League |
| 16 | 20/11/2021 | 12-1 v SV Zulte WaregemSV Zulte Waregem 1-2 KAA Gent | Belgian First Division A |
| 17 | 25/11/2021 | 10-1 v Anorthosis FamagustaAnorthosis Famagusta 1-0 KAA Gent | UEFA Europa Conference League |
| 18 | 28/11/2021 | 13-1 v Standard LiègeKAA Gent 3-1 Standard Liège | Belgian First Division A |
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